Abstract
All cells release a multitude of nanoscale extracellular vesicles (nEVs) into circulation, offering immense potential for new diagnostic strategies. Yet, clinical translation for nEVs remains a challenge due to their vast heterogeneity, our insufficient ability to isolate subpopulations, and the low frequency of disease-associated nEVs in biofluids. The growing field of nanoplasmonics is poised to address many of these challenges. Innovative materials engineering approaches based on exploiting nanoplasmonic phenomena, i.e. the unique interaction of light with nanoscale metallic materials, can achieve unrivaled sensitivity, offering real-time analysis and new modes of medical and biological imaging. We begin with an introduction into the basic structure and function of nEVs before critically reviewing recent studies utilizing nanoplasmonic platforms to detect and characterize nEVs. For the major techniques considered, surface plasmon resonance (SPR), localized SPR, and surface enhanced Raman spectroscopy (SERS), we introduce and summarize the background theory before reviewing the studies applied to nEVs. Along the way, we consider notable aspects, limitations, and considerations needed to apply plasmonic technologies to nEV detection and analysis.
| Original language | English (US) |
|---|---|
| Article number | 279 |
| Journal | Frontiers in Chemistry |
| Volume | 7 |
| Issue number | APR |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Diagnostics
- Exosomes
- LSPR
- Nanoarrays
- Nanopillars
- SERS (surface enhanced Raman scattering)
- SPR (Surface Plasmon Resonance)
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Nanoplasmonic approaches for sensitive detection and molecular characterization of extracellular vesicles. / Rojalin, Tatu; Phong, Brian; Koster, Hanna; Carney, Randy.
In: Frontiers in Chemistry, Vol. 7, No. APR, 279, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Nanoplasmonic approaches for sensitive detection and molecular characterization of extracellular vesicles
AU - Rojalin, Tatu
AU - Phong, Brian
AU - Koster, Hanna
AU - Carney, Randy
PY - 2019/1/1
Y1 - 2019/1/1
N2 - All cells release a multitude of nanoscale extracellular vesicles (nEVs) into circulation, offering immense potential for new diagnostic strategies. Yet, clinical translation for nEVs remains a challenge due to their vast heterogeneity, our insufficient ability to isolate subpopulations, and the low frequency of disease-associated nEVs in biofluids. The growing field of nanoplasmonics is poised to address many of these challenges. Innovative materials engineering approaches based on exploiting nanoplasmonic phenomena, i.e. the unique interaction of light with nanoscale metallic materials, can achieve unrivaled sensitivity, offering real-time analysis and new modes of medical and biological imaging. We begin with an introduction into the basic structure and function of nEVs before critically reviewing recent studies utilizing nanoplasmonic platforms to detect and characterize nEVs. For the major techniques considered, surface plasmon resonance (SPR), localized SPR, and surface enhanced Raman spectroscopy (SERS), we introduce and summarize the background theory before reviewing the studies applied to nEVs. Along the way, we consider notable aspects, limitations, and considerations needed to apply plasmonic technologies to nEV detection and analysis.
AB - All cells release a multitude of nanoscale extracellular vesicles (nEVs) into circulation, offering immense potential for new diagnostic strategies. Yet, clinical translation for nEVs remains a challenge due to their vast heterogeneity, our insufficient ability to isolate subpopulations, and the low frequency of disease-associated nEVs in biofluids. The growing field of nanoplasmonics is poised to address many of these challenges. Innovative materials engineering approaches based on exploiting nanoplasmonic phenomena, i.e. the unique interaction of light with nanoscale metallic materials, can achieve unrivaled sensitivity, offering real-time analysis and new modes of medical and biological imaging. We begin with an introduction into the basic structure and function of nEVs before critically reviewing recent studies utilizing nanoplasmonic platforms to detect and characterize nEVs. For the major techniques considered, surface plasmon resonance (SPR), localized SPR, and surface enhanced Raman spectroscopy (SERS), we introduce and summarize the background theory before reviewing the studies applied to nEVs. Along the way, we consider notable aspects, limitations, and considerations needed to apply plasmonic technologies to nEV detection and analysis.
KW - Diagnostics
KW - Exosomes
KW - LSPR
KW - Nanoarrays
KW - Nanopillars
KW - SERS (surface enhanced Raman scattering)
KW - SPR (Surface Plasmon Resonance)
UR - http://www.scopus.com/inward/record.url?scp=85064692977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064692977&partnerID=8YFLogxK
U2 - 10.3389/fchem.2019.00279
DO - 10.3389/fchem.2019.00279
M3 - Review article
AN - SCOPUS:85064692977
VL - 7
JO - Frontiers in Chemistry
JF - Frontiers in Chemistry
SN - 2296-2646
IS - APR
M1 - 279
ER -