Nanoparticles, lung injury, and the role of oxidant stress

Amy K. Madl, Laurel E. Plummer, Christopher Carosino, Kent E Pinkerton

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


The emergence of engineered nanoscale materials has provided significant advancements in electronic, biomedical, and material science applications. Both engineered nanoparticles and nanoparticles derived from combustion or incidental processes exhibit a range of physical and chemical properties that induce inflammation and oxidative stress in biological systems. Oxidative stress reflects the imbalance between the generation of reactive oxygen species and the biochemical mechanisms to detoxify and repair the damage resulting from reactive intermediates. This review examines current research on incidental and engineered nanoparticles in terms of their health effects on lungs and the mechanisms by which oxidative stress via physicochemical characteristics influences toxicity or biocompatibility. Although oxidative stress has generally been thought of as an adverse biological outcome, this review also briefly discusses some of the potential emerging technologies to use nanoparticle-induced oxidative stress to treat disease in a site-specific fashion. ©

Original languageEnglish (US)
Pages (from-to)447-465
Number of pages19
JournalAnnual Review of Physiology
StatePublished - Feb 2014


  • Ambient particulate matter
  • Carbon nanotubes
  • Lung
  • Nanoparticles
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology


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