Nanoformulations for molecular MRI

Chuqiao Tu, Angelique Y. Louie

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Nanoscale contrast agents have shown the ability to increase the detection sensitivity of magnetic resonance imaging (MRI) by several orders of magnitude, endowing this traditionally macroscopic modality with the ability to observe unique molecular signatures. Herein, we describe three types of nanoparticulate contrast agents: iron oxide nanoparticles, gadolinium-based nanoparticles, and bio-essential manganese, cobalt, nickel, and copper ion-containing nanoformulations. Some of these agents have been approved for clinical use, but more are still under development for medical imaging. The advantages and disadvantages of each nanoformulation, in terms of intrinsic magnetism, ease of synthesis, biodistribution, etc. are discussed.

Original languageEnglish (US)
Pages (from-to)448-457
Number of pages10
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume4
Issue number4
DOIs
StatePublished - Jul 2012

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ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)

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