Nanofibrous patches for spinal cord regeneration

Yiqian Zhu, Aijun Wang, Wenqian Shen, Shyam Patel, Rong Zhang, William L. Young, Song Li

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The difficulty in spinal cord regeneration is related to the inhibitory factors for axon growth and the lack of appropriate axon guidance in the lesion region. Here scaffolds are developed with aligned nanofibers for nerve guidance and drug delivery in the spinal cord. Blended polymers including poly(L-lactic acid) (PLLA) and poly(lactide-co-glycolide) (PLCA) are used to electrospin nanofibrous scaffolds with a two-layer structure: aligned nanofibers in the inner layer and random nanofibers in the outer layer. Rolipram, a small molecule that can enhance cAMP (cyclic adenosine monophosphate) activity in neurons and suppress inflammatory responses, is immobilized onto nanofibers. To test the therapeutic effects of nanofibrous scaffolds, the nanofibrous scaffolds loaded with rolipram are used to bridge the hemisection lesion in 8-week old athymic rats. The scaffolds with rolipram increase axon growth through the scaffolds and in the lesion, promote angiogenesis through the scaffold, and decrease the population of astrocytes and chondroitin sulfate proteoglycans in the lesion. Locomotor scale rating analysis shows that the scaffolds with rolipram significantly improved hindlimb function after 3 weeks. This study demonstrates that nanofibrous scaffolds offer a valuable platform for drug delivery for spinal cord regeneration.

Original languageEnglish (US)
Pages (from-to)1433-1440
Number of pages8
JournalAdvanced Functional Materials
Volume20
Issue number9
DOIs
StatePublished - May 10 2010

Fingerprint

spinal cord
regeneration
axons
Scaffolds
lesions
Rolipram
Nanofibers
delivery
drugs
cyclic AMP
angiogenesis
lactic acid
ratings
nerves
neurons
rats
Drug delivery
sulfates
platforms
Chondroitin Sulfate Proteoglycans

ASJC Scopus subject areas

  • Biomaterials
  • Electrochemistry
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Zhu, Y., Wang, A., Shen, W., Patel, S., Zhang, R., Young, W. L., & Li, S. (2010). Nanofibrous patches for spinal cord regeneration. Advanced Functional Materials, 20(9), 1433-1440. https://doi.org/10.1002/adfm.200901889

Nanofibrous patches for spinal cord regeneration. / Zhu, Yiqian; Wang, Aijun; Shen, Wenqian; Patel, Shyam; Zhang, Rong; Young, William L.; Li, Song.

In: Advanced Functional Materials, Vol. 20, No. 9, 10.05.2010, p. 1433-1440.

Research output: Contribution to journalArticle

Zhu, Y, Wang, A, Shen, W, Patel, S, Zhang, R, Young, WL & Li, S 2010, 'Nanofibrous patches for spinal cord regeneration', Advanced Functional Materials, vol. 20, no. 9, pp. 1433-1440. https://doi.org/10.1002/adfm.200901889
Zhu Y, Wang A, Shen W, Patel S, Zhang R, Young WL et al. Nanofibrous patches for spinal cord regeneration. Advanced Functional Materials. 2010 May 10;20(9):1433-1440. https://doi.org/10.1002/adfm.200901889
Zhu, Yiqian ; Wang, Aijun ; Shen, Wenqian ; Patel, Shyam ; Zhang, Rong ; Young, William L. ; Li, Song. / Nanofibrous patches for spinal cord regeneration. In: Advanced Functional Materials. 2010 ; Vol. 20, No. 9. pp. 1433-1440.
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