Nanofiber-supported phospholipid bilayers

Feng Yi, Jian Xu, A. Michelle Smith, Atul N. Parikh, David A. Lavan

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The natural cell cytoskeleton provides critical mechanical support for lipid bilayers using a network of actin fibers. As a step towards fabricating artificial cells, functional nanofiber networks were created to mimic the chemical and mechanical environment provided by the actin network. Lipid bilayers were formed on a random nanofiber mat made from ∼131 nm diameter polycaprolactam nanofibers modified to be highly hydrophilic by coating with 6.6 nm of silica (SiO2). The nanofiber-supported bilayers were characterized using fluorescence recovery after photobleaching (FRAP) and electrophysiological recordings and found to be comparable to bilayer recordings from natural membranes. The nanofiber-supported bilayers were also more stable than conventional, unsupported, black lipid bilayers.

Original languageEnglish (US)
Pages (from-to)5037-5041
Number of pages5
JournalSoft Matter
Volume5
Issue number24
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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