Nanoconjugates of poly(malic acid) with functional modules for drug delivery

J. Y. Ljubimova, M. Fujita, B. S. Lee, N. M. Khazenzon, Sebastian Wachsmann-Hogiu, D. L. Farkas, K. L. Black, E. Holler

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.

Original languageEnglish (US)
Title of host publication2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages354-357
Number of pages4
Volume2
Publication statusPublished - 2006
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: May 7 2006May 11 2006

Other

Other2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
CountryUnited States
CityBoston, MA
Period5/7/065/11/06

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Keywords

  • Antibodies
  • Antisense oligonucleotides
  • Fluorescence imaging
  • Tissue targeting
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Ljubimova, J. Y., Fujita, M., Lee, B. S., Khazenzon, N. M., Wachsmann-Hogiu, S., Farkas, D. L., ... Holler, E. (2006). Nanoconjugates of poly(malic acid) with functional modules for drug delivery. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings (Vol. 2, pp. 354-357)