Abstract
Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.
| Original language | English (US) |
|---|---|
| Title of host publication | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings |
| Pages | 354-357 |
| Number of pages | 4 |
| Volume | 2 |
| State | Published - 2006 |
| Event | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States Duration: May 7 2006 → May 11 2006 |
Other
| Other | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings |
|---|---|
| Country | United States |
| City | Boston, MA |
| Period | 5/7/06 → 5/11/06 |
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Keywords
- Antibodies
- Antisense oligonucleotides
- Fluorescence imaging
- Tissue targeting
- Tumor angiogenesis
ASJC Scopus subject areas
- Engineering(all)
Cite this
Nanoconjugates of poly(malic acid) with functional modules for drug delivery. / Ljubimova, J. Y.; Fujita, M.; Lee, B. S.; Khazenzon, N. M.; Wachsmann-Hogiu, Sebastian; Farkas, D. L.; Black, K. L.; Holler, E.
2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. Vol. 2 2006. p. 354-357.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Nanoconjugates of poly(malic acid) with functional modules for drug delivery
AU - Ljubimova, J. Y.
AU - Fujita, M.
AU - Lee, B. S.
AU - Khazenzon, N. M.
AU - Wachsmann-Hogiu, Sebastian
AU - Farkas, D. L.
AU - Black, K. L.
AU - Holler, E.
PY - 2006
Y1 - 2006
N2 - Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.
AB - Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.
KW - Antibodies
KW - Antisense oligonucleotides
KW - Fluorescence imaging
KW - Tissue targeting
KW - Tumor angiogenesis
UR - http://www.scopus.com/inward/record.url?scp=33845210664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845210664&partnerID=8YFLogxK
M3 - Conference contribution
SN - 0976798573
SN - 9780976798576
VL - 2
SP - 354
EP - 357
BT - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
ER -