Abstract
Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.
Original language | English (US) |
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Title of host publication | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings |
Pages | 354-357 |
Number of pages | 4 |
Volume | 2 |
State | Published - 2006 |
Event | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States Duration: May 7 2006 → May 11 2006 |
Other
Other | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings |
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Country | United States |
City | Boston, MA |
Period | 5/7/06 → 5/11/06 |
Keywords
- Antibodies
- Antisense oligonucleotides
- Fluorescence imaging
- Tissue targeting
- Tumor angiogenesis
ASJC Scopus subject areas
- Engineering(all)