Nanoconjugates of poly(malic acid) with functional modules for drug delivery

J. Y. Ljubimova; M. Fujita; B. S. Lee; N. M. Khazenzon; Sebastian Wachsmann-Hogiu; D. L. Farkas; K. L. Black; E. Holler

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

J. Y. Ljubimova, M. Fujita, B. S. Lee, N. M. Khazenzon, Sebastian Wachsmann-Hogiu, D. L. Farkas, K. L. Black, E. Holler

Pathology and Laboratory Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.

Original language	English (US)
Title of host publication	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages	354-357
Number of pages	4
Volume	2
State	Published - 2006
Event	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States Duration: May 7 2006 → May 11 2006

Other

Other	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Country	United States
City	Boston, MA
Period	5/7/06 → 5/11/06

Keywords

Antibodies
Antisense oligonucleotides
Fluorescence imaging
Tissue targeting
Tumor angiogenesis

ASJC Scopus subject areas

Engineering(all)

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Nanoconjugates of poly(malic acid) with functional modules for drug delivery. / Ljubimova, J. Y.; Fujita, M.; Lee, B. S.; Khazenzon, N. M.; Wachsmann-Hogiu, Sebastian; Farkas, D. L.; Black, K. L.; Holler, E.

2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. Vol. 2 2006. p. 354-357.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ljubimova, JY, Fujita, M, Lee, BS, Khazenzon, NM, Wachsmann-Hogiu, S, Farkas, DL, Black, KL & Holler, E 2006, Nanoconjugates of poly(malic acid) with functional modules for drug delivery. in 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. vol. 2, pp. 354-357, 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings, Boston, MA, United States, 5/7/06.

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abstract = "Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.",

keywords = "Antibodies, Antisense oligonucleotides, Fluorescence imaging, Tissue targeting, Tumor angiogenesis",

author = "Ljubimova, {J. Y.} and M. Fujita and Lee, {B. S.} and Khazenzon, {N. M.} and Sebastian Wachsmann-Hogiu and Farkas, {D. L.} and Black, {K. L.} and E. Holler",

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T1 - Nanoconjugates of poly(malic acid) with functional modules for drug delivery

AU - Ljubimova, J. Y.

AU - Fujita, M.

AU - Lee, B. S.

AU - Khazenzon, N. M.

AU - Wachsmann-Hogiu, Sebastian

AU - Farkas, D. L.

AU - Black, K. L.

AU - Holler, E.

PY - 2006

Y1 - 2006

N2 - Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.

AB - Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.

KW - Antibodies

KW - Antisense oligonucleotides

KW - Fluorescence imaging

KW - Tissue targeting

KW - Tumor angiogenesis

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