Abstract
Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold for tailored nanoconjugate chemistry. The nanoconjugate of 550 kDa allowed fluorescence imaging of brain tumor and breast cancer implanted on mouse, targeted on the basis of tumor tissue-inherent enhanced permeability and retention (EPR) and antibody recognition. The nanoconjugates were designed to inhibit tumor growth by preventing angiogenesis.
| Original language | English (US) |
|---|---|
| Title of host publication | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings |
| Pages | 354-357 |
| Number of pages | 4 |
| Volume | 2 |
| Publication status | Published - 2006 |
| Event | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States Duration: May 7 2006 → May 11 2006 |
Other
| Other | 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings |
|---|---|
| Country | United States |
| City | Boston, MA |
| Period | 5/7/06 → 5/11/06 |
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Keywords
- Antibodies
- Antisense oligonucleotides
- Fluorescence imaging
- Tissue targeting
- Tumor angiogenesis
ASJC Scopus subject areas
- Engineering(all)
Cite this
Ljubimova, J. Y., Fujita, M., Lee, B. S., Khazenzon, N. M., Wachsmann-Hogiu, S., Farkas, D. L., ... Holler, E. (2006). Nanoconjugates of poly(malic acid) with functional modules for drug delivery. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings (Vol. 2, pp. 354-357)