Nanobowtie Embedded Microfluidic Device for SERS Identification of Extracellular Vesicles from Synthetic Liposomes

Mahsa Jalali, Sayed Iman Isaac Hosseini, Tamer Abdelfatah, Laura Montermini, Sebastian Sebastian Wachsmann Hogiu, Janusz Rak, Sara Mahshid

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The need for repeated molecular analyses in facilitating precision oncology, drive the efforts to amend liquid biopsy methods. Surface enhanced Raman spectroscopy (SERS) provides a facile platform for liquid biopsy applications. The plasmonic nanomaterials represents a paradigm shift in harnessing the distinguished merits of SERS platforms and therefore of remarkable potential to enhance the sensitivity of the identification. Here, we studied the fabrication, implementation, and application of nanobowtie structures embedded in a microfluidic device for sensitive SERS identification. As a proof of principle, we evaluated the competence of the device in SERS identification of the extracellular vesicles derived from NHA cells for sensitivity. Using the nanobowtie embedded microfluidic device, we were able to distinguish a set of peaks expressed in NHA EVs populations from the artificial homogenous vesicles.

Original languageEnglish (US)
Title of host publicationNANO 2021 - 21st IEEE International Conference on Nanotechnology, Proceedings
PublisherIEEE Computer Society
Pages400-402
Number of pages3
ISBN (Electronic)9781665441568
DOIs
StatePublished - Jul 28 2021
Externally publishedYes
Event21st IEEE International Conference on Nanotechnology, NANO 2021 - Virtual, Montreal, Canada
Duration: Jul 28 2021Jul 30 2021

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
Volume2021-July
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Conference

Conference21st IEEE International Conference on Nanotechnology, NANO 2021
Country/TerritoryCanada
CityVirtual, Montreal
Period7/28/217/30/21

ASJC Scopus subject areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

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