Nano-to-microscale mechanical switches and fuses mediate adhesive contacts between leukocytes and the endothelium

Volkmar Heinrich, Andrew Leung, Evan Evans

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A test of the adhesive of attachments between leucocytes and the endothelium, and the influence of nano-to-microscale switches and fuses, using biomembrane force probe test, was described. The technique relied on membrane-embedded macromolecules that acted as a transmembrane handles. It was found that nano-to-microchemical processes played an important role in regulation of initial stages of leukocyte adhesion. The results show that mechanisms prevented permanent cell arrest at sites where blood flow was low, and enabled leukocytes to patrol vessel walls largely unaffected by variations in the bloodstream's flow rate in regions where the rate was above the shear threshold.

Original languageEnglish (US)
Pages (from-to)1482-1490
Number of pages9
JournalJournal of Chemical Information and Modeling
Volume45
Issue number6
DOIs
StatePublished - Nov 2005

Fingerprint

Electric fuses
Macromolecules
Adhesives
Blood
Adhesion
Switches
Flow rate
contact
Membranes
regulation

ASJC Scopus subject areas

  • Chemistry(all)
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Information Systems

Cite this

Nano-to-microscale mechanical switches and fuses mediate adhesive contacts between leukocytes and the endothelium. / Heinrich, Volkmar; Leung, Andrew; Evans, Evan.

In: Journal of Chemical Information and Modeling, Vol. 45, No. 6, 11.2005, p. 1482-1490.

Research output: Contribution to journalArticle

@article{b00bf87ee1884853b94e22e29ada8184,
title = "Nano-to-microscale mechanical switches and fuses mediate adhesive contacts between leukocytes and the endothelium",
abstract = "A test of the adhesive of attachments between leucocytes and the endothelium, and the influence of nano-to-microscale switches and fuses, using biomembrane force probe test, was described. The technique relied on membrane-embedded macromolecules that acted as a transmembrane handles. It was found that nano-to-microchemical processes played an important role in regulation of initial stages of leukocyte adhesion. The results show that mechanisms prevented permanent cell arrest at sites where blood flow was low, and enabled leukocytes to patrol vessel walls largely unaffected by variations in the bloodstream's flow rate in regions where the rate was above the shear threshold.",
author = "Volkmar Heinrich and Andrew Leung and Evan Evans",
year = "2005",
month = "11",
doi = "10.1021/ci0501903",
language = "English (US)",
volume = "45",
pages = "1482--1490",
journal = "Journal of Chemical Information and Computer Sciences",
issn = "0095-2338",
publisher = "American Chemical Society",
number = "6",

}

TY - JOUR

T1 - Nano-to-microscale mechanical switches and fuses mediate adhesive contacts between leukocytes and the endothelium

AU - Heinrich, Volkmar

AU - Leung, Andrew

AU - Evans, Evan

PY - 2005/11

Y1 - 2005/11

N2 - A test of the adhesive of attachments between leucocytes and the endothelium, and the influence of nano-to-microscale switches and fuses, using biomembrane force probe test, was described. The technique relied on membrane-embedded macromolecules that acted as a transmembrane handles. It was found that nano-to-microchemical processes played an important role in regulation of initial stages of leukocyte adhesion. The results show that mechanisms prevented permanent cell arrest at sites where blood flow was low, and enabled leukocytes to patrol vessel walls largely unaffected by variations in the bloodstream's flow rate in regions where the rate was above the shear threshold.

AB - A test of the adhesive of attachments between leucocytes and the endothelium, and the influence of nano-to-microscale switches and fuses, using biomembrane force probe test, was described. The technique relied on membrane-embedded macromolecules that acted as a transmembrane handles. It was found that nano-to-microchemical processes played an important role in regulation of initial stages of leukocyte adhesion. The results show that mechanisms prevented permanent cell arrest at sites where blood flow was low, and enabled leukocytes to patrol vessel walls largely unaffected by variations in the bloodstream's flow rate in regions where the rate was above the shear threshold.

UR - http://www.scopus.com/inward/record.url?scp=28944438501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28944438501&partnerID=8YFLogxK

U2 - 10.1021/ci0501903

DO - 10.1021/ci0501903

M3 - Article

VL - 45

SP - 1482

EP - 1490

JO - Journal of Chemical Information and Computer Sciences

JF - Journal of Chemical Information and Computer Sciences

SN - 0095-2338

IS - 6

ER -