Nano-to-microscale mechanical switches and fuses mediate adhesive contacts between leukocytes and the endothelium

Volkmar Heinrich, Andrew Leung, Evan Evans

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A test of the adhesive of attachments between leucocytes and the endothelium, and the influence of nano-to-microscale switches and fuses, using biomembrane force probe test, was described. The technique relied on membrane-embedded macromolecules that acted as a transmembrane handles. It was found that nano-to-microchemical processes played an important role in regulation of initial stages of leukocyte adhesion. The results show that mechanisms prevented permanent cell arrest at sites where blood flow was low, and enabled leukocytes to patrol vessel walls largely unaffected by variations in the bloodstream's flow rate in regions where the rate was above the shear threshold.

Original languageEnglish (US)
Pages (from-to)1482-1490
Number of pages9
JournalJournal of Chemical Information and Modeling
Volume45
Issue number6
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Chemistry(all)
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Information Systems

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