A test of the adhesive of attachments between leucocytes and the endothelium, and the influence of nano-to-microscale switches and fuses, using biomembrane force probe test, was described. The technique relied on membrane-embedded macromolecules that acted as a transmembrane handles. It was found that nano-to-microchemical processes played an important role in regulation of initial stages of leukocyte adhesion. The results show that mechanisms prevented permanent cell arrest at sites where blood flow was low, and enabled leukocytes to patrol vessel walls largely unaffected by variations in the bloodstream's flow rate in regions where the rate was above the shear threshold.
ASJC Scopus subject areas
- Computational Theory and Mathematics
- Computer Science Applications
- Information Systems