Abstract
In cats anesthetized with sodium pentobarbital and artificially ventilated with 70% N2O, the response of single lumbar dorsal horn units to noxious radiant heat stimuli (50°C, 10 sec) applied to glabrous footpad skin were recorded with microelectrodes. Unit heat-evoked responses were markedly suppressed by electrical stimulation (100 msec pulse trains at 100 Hz, 3/sec, 50-300 μA) at sites in the medial basal diencephalic periventricular gray, lateral hypothalamic area, preoptic area, and posterior basal telencephalon. Inhibition of dorsal horn unit responses produced by brain stimulation was not consistently affected following systemic administration of the opiate antagonist naloxone (0.5-1 mg/kg i.v.), indicating that the endogenous opioid peptides are not primarily involved in the mediation of this descending inhibition under the experimental conditions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-76 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 21 1983 |
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Keywords
- descending inhibition
- dorsal horn neuron
- medial diencephalon
- naloxone
- noxious heat
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Naloxone does not consistently affect inhibition of spinal nociceptive transmission produced by medial diencephalic stimulation in the cat. / Carstens, Earl; Guinan, M. J.; MacKinnon, J. D.
In: Neuroscience Letters, Vol. 42, No. 1, 21.11.1983, p. 71-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Naloxone does not consistently affect inhibition of spinal nociceptive transmission produced by medial diencephalic stimulation in the cat
AU - Carstens, Earl
AU - Guinan, M. J.
AU - MacKinnon, J. D.
PY - 1983/11/21
Y1 - 1983/11/21
N2 - In cats anesthetized with sodium pentobarbital and artificially ventilated with 70% N2O, the response of single lumbar dorsal horn units to noxious radiant heat stimuli (50°C, 10 sec) applied to glabrous footpad skin were recorded with microelectrodes. Unit heat-evoked responses were markedly suppressed by electrical stimulation (100 msec pulse trains at 100 Hz, 3/sec, 50-300 μA) at sites in the medial basal diencephalic periventricular gray, lateral hypothalamic area, preoptic area, and posterior basal telencephalon. Inhibition of dorsal horn unit responses produced by brain stimulation was not consistently affected following systemic administration of the opiate antagonist naloxone (0.5-1 mg/kg i.v.), indicating that the endogenous opioid peptides are not primarily involved in the mediation of this descending inhibition under the experimental conditions.
AB - In cats anesthetized with sodium pentobarbital and artificially ventilated with 70% N2O, the response of single lumbar dorsal horn units to noxious radiant heat stimuli (50°C, 10 sec) applied to glabrous footpad skin were recorded with microelectrodes. Unit heat-evoked responses were markedly suppressed by electrical stimulation (100 msec pulse trains at 100 Hz, 3/sec, 50-300 μA) at sites in the medial basal diencephalic periventricular gray, lateral hypothalamic area, preoptic area, and posterior basal telencephalon. Inhibition of dorsal horn unit responses produced by brain stimulation was not consistently affected following systemic administration of the opiate antagonist naloxone (0.5-1 mg/kg i.v.), indicating that the endogenous opioid peptides are not primarily involved in the mediation of this descending inhibition under the experimental conditions.
KW - descending inhibition
KW - dorsal horn neuron
KW - medial diencephalon
KW - naloxone
KW - noxious heat
UR - http://www.scopus.com/inward/record.url?scp=0021032901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021032901&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(83)90424-X
DO - 10.1016/0304-3940(83)90424-X
M3 - Article
C2 - 6657148
AN - SCOPUS:0021032901
VL - 42
SP - 71
EP - 76
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -