Na diffusion dependent ca handling in rabbit ventricular myocytes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Intracellular Na concentration ([Na]) plays a pivotal role in modulating the electrical and contractile activity of the heart via the Na/Ca and Na/H exchange mechanisms. Several studies showed that important [Na]i gradients exist close to the cell membrane. Thus, intracellular Na diffusion has to be slow with respect to the rates of Na transport across the sarcolemma. Here we extended the rabbit ventricular action potential and Ca transient model developed in our laboratory to establish [Na]i gradients that have been inferred directly from experimental data. In our simulations, a dramatic slowing of the Na diffusion coefficient or higher than expected colocalization between Na and Ca transporters is required to predict experimentally derived indirect effects of altered local [Na]i on Ca handling. The results suggest some directions for further laboratory investigation and modeling.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
Pages185-188
Number of pages4
Volume35
DOIs
StatePublished - 2008
EventComputers in Cardiology 2008, CAR - Bologna, Italy
Duration: Sep 14 2008Sep 17 2008

Other

OtherComputers in Cardiology 2008, CAR
CountryItaly
CityBologna
Period9/14/089/17/08

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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