@inproceedings{770109c36f1b4de6b824f137c4eb6a2b,
title = "Na: Ca stoichiometry and cytosolic Ca-dependent activation of NCX in intact cardiomyocytes",
abstract = "We are studying both Na:Ca exchange stoichiometry and cytosolic [Ca] ([Ca]i)-dependent regulation of Na-Ca exchange (NCX) in intact rabbit ventricular myocytes. Analysis of NCX fluxes in subcellular systems strongly supports a dominant 3Na:1Ca exchange, and our measurements in intact cells confirm this. However, in intact native cells, local ion gradients and other factors complicate the process of inferring stoichiometry. From a functional viewpoint, NCX stoichiometry is near 3:1 but is affected by ion accumulation/depletion as well as non-NCX fluxes. We and others have viewed [Ca]i-dependent NCX regulation as a static process (dependent on instantaneous local [Ca]i). However, evidence from subcellular and expression systems shows the process to be dynamic, and our observations confirm this to be the case in intact cardiac cells as well.",
keywords = "Ca-dependent regulation, Calcium, Na-Ca exchange, Na:Ca stoichiometry, Sodium",
author = "Bers, {Donald M} and Ginsburg, {Kenneth S}",
year = "2007",
month = mar,
doi = "10.1196/annals.1387.060",
language = "English (US)",
isbn = "1573316490",
volume = "1099",
series = "Annals of the New York Academy of Sciences",
pages = "326--338",
booktitle = "Annals of the New York Academy of Sciences",
}