N-cadherin as a key regulator of collective cell migration in a 3D environment

Wenting Shih, Soichiro Yamada

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Cell migration is a critical step of normal developmental processes and disease progression. Often, migrating cells interact and maintain contact with neighboring cells. However, the precise roles of cell-cell adhesion in cell migration have thus far been poorly defined. Often in aggressive cancers, N-cadherin is prominently upregulated, yet, these highly motile cells have limited cell-cell adhesion when plated on a stiff 2D substrate. But, the same cells in a 3D matrix migrate as a multicellular cluster. This new observation suggests that N-cadherin-mediated cell-cell adhesion supports cell interactions between migrating cells in a more physiologically relevant 3D matrix, but not on a 2D substrate. While N-cadherin is an integral part of neural synapses, the ectopic expression of N-cadherin in transformed epithelial cells plays an equally important part in initiating pro-migratory signaling, and providing strong yet flexible cell cohesion essential for persistent cell migration in a 3D matrix. The 3D cell migration analysis for studying cell-to-cell interactions exposes the roles of N-cadherin in multicellular migration, and reveals novel insights into cell migration-dependent normal and pathological processes.

Original languageEnglish (US)
Pages (from-to)513-517
Number of pages5
JournalCell Adhesion and Migration
Volume6
Issue number6
DOIs
StatePublished - Nov 2012

Fingerprint

Cadherins
Cell Movement
Cell Adhesion
Cell Communication
Pathologic Processes
Synapses
Disease Progression
Epithelial Cells
Observation

Keywords

  • 3D matrix
  • Cell migration
  • Cell-cell adhesion
  • Epithelial-to- mesenchymal transition
  • N-cadherin

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience

Cite this

N-cadherin as a key regulator of collective cell migration in a 3D environment. / Shih, Wenting; Yamada, Soichiro.

In: Cell Adhesion and Migration, Vol. 6, No. 6, 11.2012, p. 513-517.

Research output: Contribution to journalArticle

Shih, Wenting ; Yamada, Soichiro. / N-cadherin as a key regulator of collective cell migration in a 3D environment. In: Cell Adhesion and Migration. 2012 ; Vol. 6, No. 6. pp. 513-517.
@article{daf63baaab0a4936a6fa76a16462034a,
title = "N-cadherin as a key regulator of collective cell migration in a 3D environment",
abstract = "Cell migration is a critical step of normal developmental processes and disease progression. Often, migrating cells interact and maintain contact with neighboring cells. However, the precise roles of cell-cell adhesion in cell migration have thus far been poorly defined. Often in aggressive cancers, N-cadherin is prominently upregulated, yet, these highly motile cells have limited cell-cell adhesion when plated on a stiff 2D substrate. But, the same cells in a 3D matrix migrate as a multicellular cluster. This new observation suggests that N-cadherin-mediated cell-cell adhesion supports cell interactions between migrating cells in a more physiologically relevant 3D matrix, but not on a 2D substrate. While N-cadherin is an integral part of neural synapses, the ectopic expression of N-cadherin in transformed epithelial cells plays an equally important part in initiating pro-migratory signaling, and providing strong yet flexible cell cohesion essential for persistent cell migration in a 3D matrix. The 3D cell migration analysis for studying cell-to-cell interactions exposes the roles of N-cadherin in multicellular migration, and reveals novel insights into cell migration-dependent normal and pathological processes.",
keywords = "3D matrix, Cell migration, Cell-cell adhesion, Epithelial-to- mesenchymal transition, N-cadherin",
author = "Wenting Shih and Soichiro Yamada",
year = "2012",
month = "11",
doi = "10.4161/cam.21766",
language = "English (US)",
volume = "6",
pages = "513--517",
journal = "Cell Adhesion and Migration",
issn = "1933-6918",
publisher = "Landes Bioscience",
number = "6",

}

TY - JOUR

T1 - N-cadherin as a key regulator of collective cell migration in a 3D environment

AU - Shih, Wenting

AU - Yamada, Soichiro

PY - 2012/11

Y1 - 2012/11

N2 - Cell migration is a critical step of normal developmental processes and disease progression. Often, migrating cells interact and maintain contact with neighboring cells. However, the precise roles of cell-cell adhesion in cell migration have thus far been poorly defined. Often in aggressive cancers, N-cadherin is prominently upregulated, yet, these highly motile cells have limited cell-cell adhesion when plated on a stiff 2D substrate. But, the same cells in a 3D matrix migrate as a multicellular cluster. This new observation suggests that N-cadherin-mediated cell-cell adhesion supports cell interactions between migrating cells in a more physiologically relevant 3D matrix, but not on a 2D substrate. While N-cadherin is an integral part of neural synapses, the ectopic expression of N-cadherin in transformed epithelial cells plays an equally important part in initiating pro-migratory signaling, and providing strong yet flexible cell cohesion essential for persistent cell migration in a 3D matrix. The 3D cell migration analysis for studying cell-to-cell interactions exposes the roles of N-cadherin in multicellular migration, and reveals novel insights into cell migration-dependent normal and pathological processes.

AB - Cell migration is a critical step of normal developmental processes and disease progression. Often, migrating cells interact and maintain contact with neighboring cells. However, the precise roles of cell-cell adhesion in cell migration have thus far been poorly defined. Often in aggressive cancers, N-cadherin is prominently upregulated, yet, these highly motile cells have limited cell-cell adhesion when plated on a stiff 2D substrate. But, the same cells in a 3D matrix migrate as a multicellular cluster. This new observation suggests that N-cadherin-mediated cell-cell adhesion supports cell interactions between migrating cells in a more physiologically relevant 3D matrix, but not on a 2D substrate. While N-cadherin is an integral part of neural synapses, the ectopic expression of N-cadherin in transformed epithelial cells plays an equally important part in initiating pro-migratory signaling, and providing strong yet flexible cell cohesion essential for persistent cell migration in a 3D matrix. The 3D cell migration analysis for studying cell-to-cell interactions exposes the roles of N-cadherin in multicellular migration, and reveals novel insights into cell migration-dependent normal and pathological processes.

KW - 3D matrix

KW - Cell migration

KW - Cell-cell adhesion

KW - Epithelial-to- mesenchymal transition

KW - N-cadherin

UR - http://www.scopus.com/inward/record.url?scp=84872095029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872095029&partnerID=8YFLogxK

U2 - 10.4161/cam.21766

DO - 10.4161/cam.21766

M3 - Article

VL - 6

SP - 513

EP - 517

JO - Cell Adhesion and Migration

JF - Cell Adhesion and Migration

SN - 1933-6918

IS - 6

ER -