N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli

Shubhasish Mukherjee, Carolyn A. Robinson, Andrew G. Howe, Tali Mazor, Peter A. Wood, Sameer Urgaonkar, Alan M. Hebert, Debabrata RayChaudhuri, Jared T. Shaw

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20 ± 5% at 100 μM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.

Original languageEnglish (US)
Pages (from-to)6651-6655
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number23
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

Keywords

  • Antimicrobial compounds
  • Bacterial cell division
  • Library synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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  • Cite this

    Mukherjee, S., Robinson, C. A., Howe, A. G., Mazor, T., Wood, P. A., Urgaonkar, S., Hebert, A. M., RayChaudhuri, D., & Shaw, J. T. (2007). N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli. Bioorganic and Medicinal Chemistry Letters, 17(23), 6651-6655. https://doi.org/10.1016/j.bmcl.2007.09.010