Myoplasmic Ca2+ concentration during exertional rhabdomyolysis

J. R. López, M. A. Gonzalez, B. Rojas, J. R. López, A. Terzic

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Exertional rhabdomyolysis can destroy muscle but the pathophysiology is unknown. Using intracellular selective microelectrodes, we found that intracellular Ca2+ concentration ([Ca2+]i) was 1·27 (0·17) μmol/L (median and interquartile range) in skeletal-muscle biopsy specimens from patients with exertional rhabdomyolysis compared with 0·12 (0·01) μmol/L in controls. 3 days treatment with dantrolene, a drug that inhibits Ca2+ release from the sarcoplasmic reticulum, decreased [Ca2+]i to 0·22 (0·05) μmol/L and accelerated patients' recovery. This study demonstrated that exertional rhabdomyolysis is associated with elevated [Ca2+]i, and that dantrolene has a beneficial effect in this syndrome.

Original languageEnglish (US)
Pages (from-to)424-425
Number of pages2
JournalThe Lancet
Volume345
Issue number8947
DOIs
StatePublished - Feb 18 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    López, J. R., Gonzalez, M. A., Rojas, B., López, J. R., & Terzic, A. (1995). Myoplasmic Ca2+ concentration during exertional rhabdomyolysis. The Lancet, 345(8947), 424-425. https://doi.org/10.1016/S0140-6736(95)90405-0