Myophosphorylase deficiency associated with rhabdomyolysis and exercise intolerance in 6 related charolais cattle

S. Angelos, S. J. Valberg, Bradford Smith, P. S. McQuarrie, S. Shanske, S. Tsujino, S. DiMauro, G. H. Cardinet

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

A Charolais calf presented to the Veterinary Medical Teaching Hospital with a history of recumbency following forced exercise. The calf was unable to stand, and had severe rhabdomyolysis, dehydration, and electrolyte imbalance. Blood selenium concentrations were within normal limits. A complete absence of histochemical staining for phosphorylase was apparent in muscle biopsies. Five other animals in the herd also had exercise intolerance and had a complete absence of phosphorylase staining in muscle biopsies. Biochemical analyses confirmed a deficiency of myophosphorylase (range 0–0.3 μmol/g per minute: normals 15–27) with normal to slightly elevated muscle glycogen concentrations. Pedigrees from all affected animals showed a common ancestor on the sire's and dam's side of each phosphorylase‐deficient animal, suggesting an autosmal recessive transmission. Although myophosphorylase deficiency was described in humans (McArdle's disease) over 40 years ago, these cattle represent the first animal model for this disease. © 1995 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)736-740
Number of pages5
JournalMuscle & nerve
Volume18
Issue number7
DOIs
StatePublished - Jan 1 1995

Keywords

  • cattle
  • enzyme
  • glycogenosis
  • muscle
  • myophosphorylase

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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    Angelos, S., Valberg, S. J., Smith, B., McQuarrie, P. S., Shanske, S., Tsujino, S., DiMauro, S., & Cardinet, G. H. (1995). Myophosphorylase deficiency associated with rhabdomyolysis and exercise intolerance in 6 related charolais cattle. Muscle & nerve, 18(7), 736-740. https://doi.org/10.1002/mus.880180710