Abstract
Fifteen horses with pituitary pars intermedia dysfunction were studied. The horses were of various breeds and between 15 and 28 years of age. Control horses matched for breed and age were studied for comparison. Evaluations included complete blood cell count and serum biochemical analysis, electromyography, and gluteus medius muscle biopsies for histochemical, morphometric, and ultrastructural analysis. No differences were found between groups of horses on routine laboratory analysis or electromyography. We demonstrated that muscle wasting in diseased horses was the result of atrophy of types 2A and 2B muscle fibers and loss of type 2B myofibers. Mild non-specific non-inflammatory myopathic alterations such as myofiber size variation, internal nuclei, perimysial, endomysial and sarcoplasmic fat accumulation were observed. At the ultrastructural level, subsarcolemmal mitochondrial accumulation and increased lipid droplets were evident. Similar to other species, this study confirmed atrophy of type 2 fibers as the cause of muscle mass loss in horses with Cushing's disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 737-744 |
| Number of pages | 8 |
| Journal | Neuromuscular Disorders |
| Volume | 16 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2006 |
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Keywords
- Cushing's disease
- Equine
- Myopathy
- Pituitary
- Steroids
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Developmental Neuroscience
- Neurology
Cite this
Myopathy in horses with pituitary pars intermedia dysfunction (Cushing's disease). / Aleman, Monica R; Watson, Johanna L; Williams, D. C.; Lecouteur, Richard A; Nieto, Jorge; Shelton, G. D.
In: Neuromuscular Disorders, Vol. 16, No. 11, 11.2006, p. 737-744.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myopathy in horses with pituitary pars intermedia dysfunction (Cushing's disease)
AU - Aleman, Monica R
AU - Watson, Johanna L
AU - Williams, D. C.
AU - Lecouteur, Richard A
AU - Nieto, Jorge
AU - Shelton, G. D.
PY - 2006/11
Y1 - 2006/11
N2 - Fifteen horses with pituitary pars intermedia dysfunction were studied. The horses were of various breeds and between 15 and 28 years of age. Control horses matched for breed and age were studied for comparison. Evaluations included complete blood cell count and serum biochemical analysis, electromyography, and gluteus medius muscle biopsies for histochemical, morphometric, and ultrastructural analysis. No differences were found between groups of horses on routine laboratory analysis or electromyography. We demonstrated that muscle wasting in diseased horses was the result of atrophy of types 2A and 2B muscle fibers and loss of type 2B myofibers. Mild non-specific non-inflammatory myopathic alterations such as myofiber size variation, internal nuclei, perimysial, endomysial and sarcoplasmic fat accumulation were observed. At the ultrastructural level, subsarcolemmal mitochondrial accumulation and increased lipid droplets were evident. Similar to other species, this study confirmed atrophy of type 2 fibers as the cause of muscle mass loss in horses with Cushing's disease.
AB - Fifteen horses with pituitary pars intermedia dysfunction were studied. The horses were of various breeds and between 15 and 28 years of age. Control horses matched for breed and age were studied for comparison. Evaluations included complete blood cell count and serum biochemical analysis, electromyography, and gluteus medius muscle biopsies for histochemical, morphometric, and ultrastructural analysis. No differences were found between groups of horses on routine laboratory analysis or electromyography. We demonstrated that muscle wasting in diseased horses was the result of atrophy of types 2A and 2B muscle fibers and loss of type 2B myofibers. Mild non-specific non-inflammatory myopathic alterations such as myofiber size variation, internal nuclei, perimysial, endomysial and sarcoplasmic fat accumulation were observed. At the ultrastructural level, subsarcolemmal mitochondrial accumulation and increased lipid droplets were evident. Similar to other species, this study confirmed atrophy of type 2 fibers as the cause of muscle mass loss in horses with Cushing's disease.
KW - Cushing's disease
KW - Equine
KW - Myopathy
KW - Pituitary
KW - Steroids
UR - http://www.scopus.com/inward/record.url?scp=33750431749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750431749&partnerID=8YFLogxK
U2 - 10.1016/j.nmd.2006.07.019
DO - 10.1016/j.nmd.2006.07.019
M3 - Article
C2 - 17005399
AN - SCOPUS:33750431749
VL - 16
SP - 737
EP - 744
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
SN - 0960-8966
IS - 11
ER -