Myoglobin signal as an NMR tissue thermometer: implication for hyperthermia treatment of tumors

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Abstract

Measuring local tissue temperature is critical in stablishing a rational approach for hyperthermia treatment of tumors. We have found that the heme signals of myoglobin provide a unique basis for NMR thermometry in vivo. In particular the 5-methyl heme signal of MbCN exhibits a sharp, temperature-dependent resonance that is distinguishable in the tissue spectrum. Its calibrated chemical shift can then reflect the local tissue temperature in vivo.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalBBA - Molecular Basis of Disease
Volume1226
Issue number1
DOIs
StatePublished - Apr 12 1994

Keywords

  • Hyperthermia
  • Myoglobin
  • NMR
  • Thermometry
  • Tumor

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Molecular Medicine

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