Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes

E. Olson, D. Edmondson, W. E. Wright, V. K. Lin, J. L. Guenet, D. Simon-Chazottes, L. H. Thompson, R. L. Stallings, W. T. Schroeder, M. Duvic, D. Brock, D. Helin, M. J. Siciliano

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Abstract

Myogenin is a member of a family of muscle-specific regulatory factors which includes MyoD1, Myf-5, and Myf-6 (also called MRF4 and herculin). Extensive regions of sequence homology in genes for these three factors suggest duplication events associated with their evolution. In the present study, the chromosomal location of the myogenin gene in humans (MYOG), mice (Myog), and Chinese hamsters (MYOG) was determined using in situ hybridization to human metaphase chromosomes as well as segregation analysis among interspecific somatic cell hybrid panels and interspecific backcrossed mice. We localize the gene encoding myogenin to human chromosome 1q31-q41 within a linkage group homologous with a region on mouse chromosome 1 and Chinese hamster chromosome 5. The results verify the nonlinkage of MYOG to MYOD1, MYF5, and MYF6 genes and indicate that events associated with the duplication of MYOG with respect to MYOD1, MYF5, or MYF6 loci were not chromosome-wide.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalGenomics
Volume8
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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Myogenin
Human Chromosomes
Regulator Genes
Muscles
Genes
Cricetulus
Chromosomes, Human, Pair 5
Gene Duplication
Hybrid Cells
Chromosomes, Human, Pair 1
Metaphase
Sequence Homology
In Situ Hybridization
Chromosomes
myogenic factor 6

ASJC Scopus subject areas

  • Genetics

Cite this

Olson, E., Edmondson, D., Wright, W. E., Lin, V. K., Guenet, J. L., Simon-Chazottes, D., ... Siciliano, M. J. (1990). Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes. Genomics, 8(3), 427-434. https://doi.org/10.1016/0888-7543(90)90028-S

Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes. / Olson, E.; Edmondson, D.; Wright, W. E.; Lin, V. K.; Guenet, J. L.; Simon-Chazottes, D.; Thompson, L. H.; Stallings, R. L.; Schroeder, W. T.; Duvic, M.; Brock, D.; Helin, D.; Siciliano, M. J.

In: Genomics, Vol. 8, No. 3, 1990, p. 427-434.

Research output: Contribution to journalArticle

Olson, E, Edmondson, D, Wright, WE, Lin, VK, Guenet, JL, Simon-Chazottes, D, Thompson, LH, Stallings, RL, Schroeder, WT, Duvic, M, Brock, D, Helin, D & Siciliano, MJ 1990, 'Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes', Genomics, vol. 8, no. 3, pp. 427-434. https://doi.org/10.1016/0888-7543(90)90028-S
Olson, E. ; Edmondson, D. ; Wright, W. E. ; Lin, V. K. ; Guenet, J. L. ; Simon-Chazottes, D. ; Thompson, L. H. ; Stallings, R. L. ; Schroeder, W. T. ; Duvic, M. ; Brock, D. ; Helin, D. ; Siciliano, M. J. / Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes. In: Genomics. 1990 ; Vol. 8, No. 3. pp. 427-434.
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abstract = "Myogenin is a member of a family of muscle-specific regulatory factors which includes MyoD1, Myf-5, and Myf-6 (also called MRF4 and herculin). Extensive regions of sequence homology in genes for these three factors suggest duplication events associated with their evolution. In the present study, the chromosomal location of the myogenin gene in humans (MYOG), mice (Myog), and Chinese hamsters (MYOG) was determined using in situ hybridization to human metaphase chromosomes as well as segregation analysis among interspecific somatic cell hybrid panels and interspecific backcrossed mice. We localize the gene encoding myogenin to human chromosome 1q31-q41 within a linkage group homologous with a region on mouse chromosome 1 and Chinese hamster chromosome 5. The results verify the nonlinkage of MYOG to MYOD1, MYF5, and MYF6 genes and indicate that events associated with the duplication of MYOG with respect to MYOD1, MYF5, or MYF6 loci were not chromosome-wide.",
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AU - Thompson, L. H.

AU - Stallings, R. L.

AU - Schroeder, W. T.

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AU - Brock, D.

AU - Helin, D.

AU - Siciliano, M. J.

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