Abstract
Objectives: Myoepithelial carcinoma is a rare neoplasm of salivary gland origin. The tumor cells demonstrate morphologic, immunohistochemical and electron-microscopic features of myoepithelial cells and lack ductal and acinar differentiation. Only one series of 10 compiled cases exists in the literature. An additional 7 cases have been reported. The clinical behavior is that of a malignant tumor with a tendency for local recurrence and a propensity for distant metastases. Material and Methods: We add our experience of 2 cases of myoepithelial carcinoma. Both cases arose in the parotid gland. A myoepithelioma had been excised via a parotidectomy several years prior to the presentation with myoepithelial carcinoma. In addition one of the patients demonstrated distant osseous metastases. To our knowledge neither of these features have previously been reported in the literature. Results and Conclusions: The histological features of myoepithelioma and myoepithelial carcinoma are compared. The histogenesis of these unusual tumors, natural history and treatment are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 220-226 |
| Number of pages | 7 |
| Journal | Oto-Rhino-Laryngologia Nova |
| Volume | 7 |
| Issue number | 5-6 |
| State | Published - 1997 |
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Keywords
- Myoepithelial carcinoma
- Myoepithelioma
- Salivary malignancy
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Myoepithelial carcinoma : A report of two cases and review of the literature. / Manolidis, Spiros; Donald, Paul J.; Gandour-Edwards, Regina F.
In: Oto-Rhino-Laryngologia Nova, Vol. 7, No. 5-6, 1997, p. 220-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myoepithelial carcinoma
T2 - A report of two cases and review of the literature
AU - Manolidis, Spiros
AU - Donald, Paul J.
AU - Gandour-Edwards, Regina F
PY - 1997
Y1 - 1997
N2 - Objectives: Myoepithelial carcinoma is a rare neoplasm of salivary gland origin. The tumor cells demonstrate morphologic, immunohistochemical and electron-microscopic features of myoepithelial cells and lack ductal and acinar differentiation. Only one series of 10 compiled cases exists in the literature. An additional 7 cases have been reported. The clinical behavior is that of a malignant tumor with a tendency for local recurrence and a propensity for distant metastases. Material and Methods: We add our experience of 2 cases of myoepithelial carcinoma. Both cases arose in the parotid gland. A myoepithelioma had been excised via a parotidectomy several years prior to the presentation with myoepithelial carcinoma. In addition one of the patients demonstrated distant osseous metastases. To our knowledge neither of these features have previously been reported in the literature. Results and Conclusions: The histological features of myoepithelioma and myoepithelial carcinoma are compared. The histogenesis of these unusual tumors, natural history and treatment are discussed.
AB - Objectives: Myoepithelial carcinoma is a rare neoplasm of salivary gland origin. The tumor cells demonstrate morphologic, immunohistochemical and electron-microscopic features of myoepithelial cells and lack ductal and acinar differentiation. Only one series of 10 compiled cases exists in the literature. An additional 7 cases have been reported. The clinical behavior is that of a malignant tumor with a tendency for local recurrence and a propensity for distant metastases. Material and Methods: We add our experience of 2 cases of myoepithelial carcinoma. Both cases arose in the parotid gland. A myoepithelioma had been excised via a parotidectomy several years prior to the presentation with myoepithelial carcinoma. In addition one of the patients demonstrated distant osseous metastases. To our knowledge neither of these features have previously been reported in the literature. Results and Conclusions: The histological features of myoepithelioma and myoepithelial carcinoma are compared. The histogenesis of these unusual tumors, natural history and treatment are discussed.
KW - Myoepithelial carcinoma
KW - Myoepithelioma
KW - Salivary malignancy
UR - http://www.scopus.com/inward/record.url?scp=0031393583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031393583&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0031393583
VL - 7
SP - 220
EP - 226
JO - Oto-Rhino-Laryngologia Nova
JF - Oto-Rhino-Laryngologia Nova
SN - 1014-8221
IS - 5-6
ER -