Myocyte adrenoceptor signaling pathways

Yang Kevin Xiang, Brian K. Kobilka

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Adrenoceptors (ARs), members of the G protein-coupled receptor superfamily, form the interface between the sympathetic nervous system and the cardiovascular system, with integral roles in the rapid regulation of myocardial function. However, in heart failure, chronic catecholamine stimulation of adrenoceptors has been linked to pathologic cardiac remodeling, including myocyte apoptosis and hypertrophy. In cardiac myocytes, activation of AR subtypes results in coupling to different G proteins and induction of specific signaling pathways, which is partly regulated by the subtype-specific distribution of receptors in plasma membrane compartments containing distinct complexes of signaling molecules. The Connections Maps of the Adrenergic and Myocyte Adrenergic Signaling Pathways bring into focus the specific signaling pathways of individual AR subtypes and their relevant functions in vivo.

Original languageEnglish (US)
Pages (from-to)1530-1532
Number of pages3
JournalScience
Volume300
Issue number5625
DOIs
StatePublished - Jun 6 2003
Externally publishedYes

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Adrenergic Receptors
Muscle Cells
Adrenergic Agents
Sympathetic Nervous System
G-Protein-Coupled Receptors
Cardiovascular System
GTP-Binding Proteins
Cardiac Myocytes
Hypertrophy
Catecholamines
Heart Failure
Cell Membrane
Apoptosis

ASJC Scopus subject areas

  • General

Cite this

Myocyte adrenoceptor signaling pathways. / Xiang, Yang Kevin; Kobilka, Brian K.

In: Science, Vol. 300, No. 5625, 06.06.2003, p. 1530-1532.

Research output: Contribution to journalArticle

Xiang, Yang Kevin ; Kobilka, Brian K. / Myocyte adrenoceptor signaling pathways. In: Science. 2003 ; Vol. 300, No. 5625. pp. 1530-1532.
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