Myeloperoxidase, a leukocyte-derived vascular NO oxidase

Jason P. Eiserich, Stephan Baldus, Marie Luise Brennan, Wenxin Ma, Chunxiang Zhang, Albert Tousson, Laura Castro, Aldons J. Lusis, William M. Nauseef, C. Roger White, Bruce A. Freeman

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527 Scopus citations

Abstract

Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. Although its microbicidal functions are well established in vitro, humans deficient in MPO are not at unusual risk of infection. MPO was observed herein to modulate the vascular signaling and vasodilatory functions of nitric oxide (NO) during acute inflammation. After leukocyte degranulation. MPO localized in and around vascular endothelial cells in a rodent model of acute endotoxemia and impaired endothelium-dependent relaxant responses, to which MPO-deficient mice were resistant. Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability.

Original languageEnglish (US)
Pages (from-to)2391-2394
Number of pages4
JournalScience
Volume296
Issue number5577
DOIs
StatePublished - Jun 28 2002

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    Eiserich, J. P., Baldus, S., Brennan, M. L., Ma, W., Zhang, C., Tousson, A., Castro, L., Lusis, A. J., Nauseef, W. M., White, C. R., & Freeman, B. A. (2002). Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science, 296(5577), 2391-2394. https://doi.org/10.1126/science.1106830