Myeloid Cells and Chronic Liver Disease: a Comprehensive Review

Min Lian, Carlo Selmi, M. Eric Gershwin, Xiong Ma

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Myeloid cells play a major role in the sensitization to liver injury, particularly in chronic inflammatory liver diseases with a biliary or hepatocellular origin, and the interplay between myeloid cells and the liver may explain the increased incidence of hepatic osteodystrophy. The myeloid cell-liver axis involves several mature myeloid cells as well as immature or progenitor cells with the complexity of the liver immune microenvironment aggravating the mist of cell differentiation. The unique positioning of the liver at the junction of the peripheral and portal circulation systems underlines the interaction of myeloid cells and hepatic cells and leads to immune tolerance breakdown. We herein discuss the scenarios of different chronic liver diseases closely modulated by myeloid cells and illustrate the numerous potential targets, the understanding of which will ultimately steer the development of solid immunotherapeutic regimens. Ultimately, we are convinced that an adequate modulation of the liver microenvironment to modify the functional and quantitative characteristics of myeloid cells will be a successful approach to treating chronic liver diseases of different etiologies.

Original languageEnglish (US)
Pages (from-to)307-317
Number of pages11
JournalClinical Reviews in Allergy and Immunology
Volume54
Issue number2
DOIs
StatePublished - Apr 1 2018

Fingerprint

Myeloid Cells
Liver Diseases
Chronic Disease
Liver
Portal System
Immune Tolerance
Cell Differentiation
Hepatocytes
Stem Cells
Incidence
Wounds and Injuries

Keywords

  • Chronic inflammatory liver diseases
  • Hepatic osteodystrophy
  • Myeloid cell
  • Myeloid cell-liver axis

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Myeloid Cells and Chronic Liver Disease : a Comprehensive Review. / Lian, Min; Selmi, Carlo; Gershwin, M. Eric; Ma, Xiong.

In: Clinical Reviews in Allergy and Immunology, Vol. 54, No. 2, 01.04.2018, p. 307-317.

Research output: Contribution to journalReview article

@article{7d7b45434c1944fa82ec79227b778fc6,
title = "Myeloid Cells and Chronic Liver Disease: a Comprehensive Review",
abstract = "Myeloid cells play a major role in the sensitization to liver injury, particularly in chronic inflammatory liver diseases with a biliary or hepatocellular origin, and the interplay between myeloid cells and the liver may explain the increased incidence of hepatic osteodystrophy. The myeloid cell-liver axis involves several mature myeloid cells as well as immature or progenitor cells with the complexity of the liver immune microenvironment aggravating the mist of cell differentiation. The unique positioning of the liver at the junction of the peripheral and portal circulation systems underlines the interaction of myeloid cells and hepatic cells and leads to immune tolerance breakdown. We herein discuss the scenarios of different chronic liver diseases closely modulated by myeloid cells and illustrate the numerous potential targets, the understanding of which will ultimately steer the development of solid immunotherapeutic regimens. Ultimately, we are convinced that an adequate modulation of the liver microenvironment to modify the functional and quantitative characteristics of myeloid cells will be a successful approach to treating chronic liver diseases of different etiologies.",
keywords = "Chronic inflammatory liver diseases, Hepatic osteodystrophy, Myeloid cell, Myeloid cell-liver axis",
author = "Min Lian and Carlo Selmi and Gershwin, {M. Eric} and Xiong Ma",
year = "2018",
month = "4",
day = "1",
doi = "10.1007/s12016-017-8664-x",
language = "English (US)",
volume = "54",
pages = "307--317",
journal = "Clinical Reviews in Allergy and Immunology",
issn = "1080-0549",
publisher = "Humana Press",
number = "2",

}

TY - JOUR

T1 - Myeloid Cells and Chronic Liver Disease

T2 - a Comprehensive Review

AU - Lian, Min

AU - Selmi, Carlo

AU - Gershwin, M. Eric

AU - Ma, Xiong

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Myeloid cells play a major role in the sensitization to liver injury, particularly in chronic inflammatory liver diseases with a biliary or hepatocellular origin, and the interplay between myeloid cells and the liver may explain the increased incidence of hepatic osteodystrophy. The myeloid cell-liver axis involves several mature myeloid cells as well as immature or progenitor cells with the complexity of the liver immune microenvironment aggravating the mist of cell differentiation. The unique positioning of the liver at the junction of the peripheral and portal circulation systems underlines the interaction of myeloid cells and hepatic cells and leads to immune tolerance breakdown. We herein discuss the scenarios of different chronic liver diseases closely modulated by myeloid cells and illustrate the numerous potential targets, the understanding of which will ultimately steer the development of solid immunotherapeutic regimens. Ultimately, we are convinced that an adequate modulation of the liver microenvironment to modify the functional and quantitative characteristics of myeloid cells will be a successful approach to treating chronic liver diseases of different etiologies.

AB - Myeloid cells play a major role in the sensitization to liver injury, particularly in chronic inflammatory liver diseases with a biliary or hepatocellular origin, and the interplay between myeloid cells and the liver may explain the increased incidence of hepatic osteodystrophy. The myeloid cell-liver axis involves several mature myeloid cells as well as immature or progenitor cells with the complexity of the liver immune microenvironment aggravating the mist of cell differentiation. The unique positioning of the liver at the junction of the peripheral and portal circulation systems underlines the interaction of myeloid cells and hepatic cells and leads to immune tolerance breakdown. We herein discuss the scenarios of different chronic liver diseases closely modulated by myeloid cells and illustrate the numerous potential targets, the understanding of which will ultimately steer the development of solid immunotherapeutic regimens. Ultimately, we are convinced that an adequate modulation of the liver microenvironment to modify the functional and quantitative characteristics of myeloid cells will be a successful approach to treating chronic liver diseases of different etiologies.

KW - Chronic inflammatory liver diseases

KW - Hepatic osteodystrophy

KW - Myeloid cell

KW - Myeloid cell-liver axis

UR - http://www.scopus.com/inward/record.url?scp=85044668319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044668319&partnerID=8YFLogxK

U2 - 10.1007/s12016-017-8664-x

DO - 10.1007/s12016-017-8664-x

M3 - Review article

C2 - 29313221

AN - SCOPUS:85044668319

VL - 54

SP - 307

EP - 317

JO - Clinical Reviews in Allergy and Immunology

JF - Clinical Reviews in Allergy and Immunology

SN - 1080-0549

IS - 2

ER -