Myelin injury and degraded myelin vesicles in Alzheimer's disease

Xinhua Zhan, Glen C. Jickling, Bradley Ander, Da Liu, Boryana Stamova, Christopher Cox, Lee-Way Jin, Charles DeCarli, Frank R Sharp

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Objective: Myelin disruption is an important feature of Alzheimer's disease (AD) that contributes to impairment of neuronal circuitry and cognition. In this study we characterize myelin degradation in the brains of patients with Alzheimer's disease compared with normal aged controls. Methods: Myelin from patients with AD (n=13) was compared to matched controls (n=6). Myelin degradation was examined by immunohistochemistry in frontal white matter (WM) for intact myelin basic protein (MBP), degraded MBP, the presence of myelin lipid and for PAS staining. The relationship of myelin degradation and axonal injury was also assessed. Results: Brains from patients with AD had significant loss of intact MBP, and an increase in degraded MBP in periventricular WM adjacent to a denuded ependymal layer. In regions of myelin degradation, vesicles were identified that stained positive for degraded MBP, myelin lipid, and neurofilament but not for intact MBP. Most vesicles stained for PAS, a corpora amylacea marker. The vesicles were significantly more abundant in the periventricular WM of AD patients compared to controls (44.5±11.0 versus 1.7±1.1, p=0.02). Conclusion: In AD patients degraded MBP is associated in part with vesicles particularly in periventricular WM that is adjacent to areas of ependymal injury.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalCurrent Alzheimer Research
Volume11
Issue number3
DOIs
StatePublished - 2014

Keywords

  • Alzheimer's
  • Corpora amylacea
  • Ependyma
  • Myelin basic protein
  • Myelin degradation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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