Myelin gene expression in glia treated with oligodendroglial trophic factor

B. Q. Krelder, M. M. Burns, J. B. Grinspan, M. Morley, I. A. Panek, R. Shaw, David E Pleasure

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Oligodendroglia synthesize myelin in the CNS. in vitro, oligodendroglia may be identified by the binding of monoclonal antibodies against galactocerebroside, a myelin-specific galactolipid. Oligodendroglial trophic factor is a protein mitogen for cells of the oligodendroglial lineage. When oligodendroglia in cerebral white matter cultures are treated with oligodendroglial trophic factor, galactocerebroside-positive cells undergo mitosis but fail to express the myelin structural proteins, myelin basic protein and proteolipid protein. Oligodendroglia treated with oligodendroglial trophic factor, however, do express 2′, 3′-cyclic nucleotide 3′-phosphodiesterase and myelin-associated glycoprotein in a manner similar to oligodendroglia treated with platelet-derived growth factor. Oligodendroglial trophic factor, therefore, generates a population of somewhat 'immature' oligodendroglia, which are galactocerebroside, myelin-associated glycoprotein and 2′, 3′-cyclic nucleotide 3′ phosphodiesterase positive but myelin basic protein and proteolipid protein negative.

Original languageEnglish (US)
Pages (from-to)725-734
Number of pages10
JournalJournal of Neurocytology
Volume24
Issue number10
DOIs
StatePublished - Oct 1995
Externally publishedYes

Fingerprint

Oligodendroglia
Myelin Sheath
Neuroglia
Gene Expression
Myelin-Associated Glycoprotein
Proteolipids
Myelin Basic Protein
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Galactolipids
Myelin Proteins
Proteins
Platelet-Derived Growth Factor
Cell Lineage
Mitogens
Mitosis
Monoclonal Antibodies
Population
galactocerebroside

ASJC Scopus subject areas

  • Neuroscience(all)
  • Histology
  • Anatomy
  • Cell Biology

Cite this

Krelder, B. Q., Burns, M. M., Grinspan, J. B., Morley, M., Panek, I. A., Shaw, R., & Pleasure, D. E. (1995). Myelin gene expression in glia treated with oligodendroglial trophic factor. Journal of Neurocytology, 24(10), 725-734. https://doi.org/10.1007/BF01191209

Myelin gene expression in glia treated with oligodendroglial trophic factor. / Krelder, B. Q.; Burns, M. M.; Grinspan, J. B.; Morley, M.; Panek, I. A.; Shaw, R.; Pleasure, David E.

In: Journal of Neurocytology, Vol. 24, No. 10, 10.1995, p. 725-734.

Research output: Contribution to journalArticle

Krelder, BQ, Burns, MM, Grinspan, JB, Morley, M, Panek, IA, Shaw, R & Pleasure, DE 1995, 'Myelin gene expression in glia treated with oligodendroglial trophic factor', Journal of Neurocytology, vol. 24, no. 10, pp. 725-734. https://doi.org/10.1007/BF01191209
Krelder BQ, Burns MM, Grinspan JB, Morley M, Panek IA, Shaw R et al. Myelin gene expression in glia treated with oligodendroglial trophic factor. Journal of Neurocytology. 1995 Oct;24(10):725-734. https://doi.org/10.1007/BF01191209
Krelder, B. Q. ; Burns, M. M. ; Grinspan, J. B. ; Morley, M. ; Panek, I. A. ; Shaw, R. ; Pleasure, David E. / Myelin gene expression in glia treated with oligodendroglial trophic factor. In: Journal of Neurocytology. 1995 ; Vol. 24, No. 10. pp. 725-734.
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