Abstract
Oligodendroglia synthesize myelin in the CNS. in vitro, oligodendroglia may be identified by the binding of monoclonal antibodies against galactocerebroside, a myelin-specific galactolipid. Oligodendroglial trophic factor is a protein mitogen for cells of the oligodendroglial lineage. When oligodendroglia in cerebral white matter cultures are treated with oligodendroglial trophic factor, galactocerebroside-positive cells undergo mitosis but fail to express the myelin structural proteins, myelin basic protein and proteolipid protein. Oligodendroglia treated with oligodendroglial trophic factor, however, do express 2′, 3′-cyclic nucleotide 3′-phosphodiesterase and myelin-associated glycoprotein in a manner similar to oligodendroglia treated with platelet-derived growth factor. Oligodendroglial trophic factor, therefore, generates a population of somewhat 'immature' oligodendroglia, which are galactocerebroside, myelin-associated glycoprotein and 2′, 3′-cyclic nucleotide 3′ phosphodiesterase positive but myelin basic protein and proteolipid protein negative.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 725-734 |
| Number of pages | 10 |
| Journal | Journal of Neurocytology |
| Volume | 24 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
- Histology
- Anatomy
- Cell Biology
Cite this
Myelin gene expression in glia treated with oligodendroglial trophic factor. / Krelder, B. Q.; Burns, M. M.; Grinspan, J. B.; Morley, M.; Panek, I. A.; Shaw, R.; Pleasure, David E.
In: Journal of Neurocytology, Vol. 24, No. 10, 10.1995, p. 725-734.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myelin gene expression in glia treated with oligodendroglial trophic factor
AU - Krelder, B. Q.
AU - Burns, M. M.
AU - Grinspan, J. B.
AU - Morley, M.
AU - Panek, I. A.
AU - Shaw, R.
AU - Pleasure, David E
PY - 1995/10
Y1 - 1995/10
N2 - Oligodendroglia synthesize myelin in the CNS. in vitro, oligodendroglia may be identified by the binding of monoclonal antibodies against galactocerebroside, a myelin-specific galactolipid. Oligodendroglial trophic factor is a protein mitogen for cells of the oligodendroglial lineage. When oligodendroglia in cerebral white matter cultures are treated with oligodendroglial trophic factor, galactocerebroside-positive cells undergo mitosis but fail to express the myelin structural proteins, myelin basic protein and proteolipid protein. Oligodendroglia treated with oligodendroglial trophic factor, however, do express 2′, 3′-cyclic nucleotide 3′-phosphodiesterase and myelin-associated glycoprotein in a manner similar to oligodendroglia treated with platelet-derived growth factor. Oligodendroglial trophic factor, therefore, generates a population of somewhat 'immature' oligodendroglia, which are galactocerebroside, myelin-associated glycoprotein and 2′, 3′-cyclic nucleotide 3′ phosphodiesterase positive but myelin basic protein and proteolipid protein negative.
AB - Oligodendroglia synthesize myelin in the CNS. in vitro, oligodendroglia may be identified by the binding of monoclonal antibodies against galactocerebroside, a myelin-specific galactolipid. Oligodendroglial trophic factor is a protein mitogen for cells of the oligodendroglial lineage. When oligodendroglia in cerebral white matter cultures are treated with oligodendroglial trophic factor, galactocerebroside-positive cells undergo mitosis but fail to express the myelin structural proteins, myelin basic protein and proteolipid protein. Oligodendroglia treated with oligodendroglial trophic factor, however, do express 2′, 3′-cyclic nucleotide 3′-phosphodiesterase and myelin-associated glycoprotein in a manner similar to oligodendroglia treated with platelet-derived growth factor. Oligodendroglial trophic factor, therefore, generates a population of somewhat 'immature' oligodendroglia, which are galactocerebroside, myelin-associated glycoprotein and 2′, 3′-cyclic nucleotide 3′ phosphodiesterase positive but myelin basic protein and proteolipid protein negative.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028848594&partnerID=8YFLogxK
U2 - 10.1007/BF01191209
DO - 10.1007/BF01191209
M3 - Article
C2 - 8586993
AN - SCOPUS:0028848594
VL - 24
SP - 725
EP - 734
JO - Journal of Neurocytology
JF - Journal of Neurocytology
SN - 0300-4864
IS - 10
ER -