Abstract
Oligodendroglia synthesize myelin in the CNS. in vitro, oligodendroglia may be identified by the binding of monoclonal antibodies against galactocerebroside, a myelin-specific galactolipid. Oligodendroglial trophic factor is a protein mitogen for cells of the oligodendroglial lineage. When oligodendroglia in cerebral white matter cultures are treated with oligodendroglial trophic factor, galactocerebroside-positive cells undergo mitosis but fail to express the myelin structural proteins, myelin basic protein and proteolipid protein. Oligodendroglia treated with oligodendroglial trophic factor, however, do express 2′, 3′-cyclic nucleotide 3′-phosphodiesterase and myelin-associated glycoprotein in a manner similar to oligodendroglia treated with platelet-derived growth factor. Oligodendroglial trophic factor, therefore, generates a population of somewhat 'immature' oligodendroglia, which are galactocerebroside, myelin-associated glycoprotein and 2′, 3′-cyclic nucleotide 3′ phosphodiesterase positive but myelin basic protein and proteolipid protein negative.
Original language | English (US) |
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Pages (from-to) | 725-734 |
Number of pages | 10 |
Journal | Journal of Neurocytology |
Volume | 24 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)
- Histology
- Anatomy
- Cell Biology