Myelin-associated glycoprotein in human retina

K. Stefansson, M. L. Molnar, L. S. Marton, G. K. Molnar, M. Mihovilovic, R. C. Tripathi, David P Richman

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Abstract

The human retina is unmyelinated, but structural similarities have been noted between Müller cells, the main glial cell type of retina, and oligodendrocytes, the myelin-forming cells of the central nervous system 1. We now show that antibodies against myelin-associated glycoprotein, a minor component of central and peripheral myelin so far found only in myelin and myelin-forming cells2-4, also stain Müller cells. Immunoblot analysis of retinal proteins indicates that the antigen detected is myelin associated glycoprotein. These results suggest a closer relationship between Müller cells and oligodendrocytes than previously suspected and raise questions about the functional role of myelin-associated glycoprotein.

Original languageEnglish (US)
Pages (from-to)548-550
Number of pages3
JournalNature
Volume307
Issue number5951
DOIs
StatePublished - 1984
Externally publishedYes

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Cite this

Stefansson, K., Molnar, M. L., Marton, L. S., Molnar, G. K., Mihovilovic, M., Tripathi, R. C., & Richman, D. P. (1984). Myelin-associated glycoprotein in human retina. Nature, 307(5951), 548-550. https://doi.org/10.1038/307548a0