Myelin-associated glycoprotein in human retina

K. Stefansson, M. L. Molnar, L. S. Marton, G. K. Molnar, M. Mihovilovic, R. C. Tripathi, David P Richman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The human retina is unmyelinated, but structural similarities have been noted between Müller cells, the main glial cell type of retina, and oligodendrocytes, the myelin-forming cells of the central nervous system 1. We now show that antibodies against myelin-associated glycoprotein, a minor component of central and peripheral myelin so far found only in myelin and myelin-forming cells2-4, also stain Müller cells. Immunoblot analysis of retinal proteins indicates that the antigen detected is myelin associated glycoprotein. These results suggest a closer relationship between Müller cells and oligodendrocytes than previously suspected and raise questions about the functional role of myelin-associated glycoprotein.

Original languageEnglish (US)
Pages (from-to)548-550
Number of pages3
JournalNature
Volume307
Issue number5951
DOIs
StatePublished - 1984
Externally publishedYes

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Myelin-Associated Glycoprotein
Myelin Sheath
Retina
Oligodendroglia
Neuroglia
Coloring Agents
Central Nervous System
Antigens
human MAG protein
Antibodies
Proteins

ASJC Scopus subject areas

  • General

Cite this

Stefansson, K., Molnar, M. L., Marton, L. S., Molnar, G. K., Mihovilovic, M., Tripathi, R. C., & Richman, D. P. (1984). Myelin-associated glycoprotein in human retina. Nature, 307(5951), 548-550. https://doi.org/10.1038/307548a0

Myelin-associated glycoprotein in human retina. / Stefansson, K.; Molnar, M. L.; Marton, L. S.; Molnar, G. K.; Mihovilovic, M.; Tripathi, R. C.; Richman, David P.

In: Nature, Vol. 307, No. 5951, 1984, p. 548-550.

Research output: Contribution to journalArticle

Stefansson, K, Molnar, ML, Marton, LS, Molnar, GK, Mihovilovic, M, Tripathi, RC & Richman, DP 1984, 'Myelin-associated glycoprotein in human retina', Nature, vol. 307, no. 5951, pp. 548-550. https://doi.org/10.1038/307548a0
Stefansson K, Molnar ML, Marton LS, Molnar GK, Mihovilovic M, Tripathi RC et al. Myelin-associated glycoprotein in human retina. Nature. 1984;307(5951):548-550. https://doi.org/10.1038/307548a0
Stefansson, K. ; Molnar, M. L. ; Marton, L. S. ; Molnar, G. K. ; Mihovilovic, M. ; Tripathi, R. C. ; Richman, David P. / Myelin-associated glycoprotein in human retina. In: Nature. 1984 ; Vol. 307, No. 5951. pp. 548-550.
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