Mycotic infections acquired outside areas of known endemicity, United States

Kaitlin Benedict, George Richard Thompson, Stan Deresinski, Tom Chiller

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


In the United States, endemic mycoses—blastomycosis, coccidioidomycosis, and histoplasmosis—pose considerable clinical and public health challenges. Although the causative fungi typically exist within broadly defined geographic areas or ecologic niches, some evidence suggests that cases have occurred in humans and animals not exposed to these areas. We describe cases acquired outside regions of traditionally defined endemicity. These patients often have severe disease, but diagnosis may be delayed because of a low index of suspicion for mycotic disease, and many more cases probably go entirely undetected. Increased awareness of these diseases, with a specific focus on their potential occurrence in unusual areas, is needed. Continued interdisciplinary efforts to reevaluate and better describe areas of true endemicity are warranted, along with a more nuanced view of the notion of endemicity. The term “nonendemic” should be used with care, mycoses in such regions might more accurately be considered “not known to be endemic.”

Original languageEnglish (US)
Pages (from-to)1935-1941
Number of pages7
JournalEmerging Infectious Diseases
Issue number11
StatePublished - Nov 1 2015

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology


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