Myc goes global: New tricks for an old oncogene

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Myc, a transcription factor commonly deregulated in tumorigenesis, is thought to mediate its diverse cellular effects by altering the expression of specific target genes. However, it has been difficult to gain a precise understanding of how Myc drives cancer because Myc acts rather weakly at many of its target loci, and it has been reported to regulate as many as 10% to 15% of all cellular genes. A new perspective on this issue has been provided by a recent study that revealed Myc can regulate chromatin structure in a global fashion. These findings suggest actions for Myc that extend beyond the traditional concept of a targeted gene regulator.

Original languageEnglish (US)
Pages (from-to)5061-5063
Number of pages3
JournalCancer Research
Volume67
Issue number11
DOIs
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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