Myc goes global: New tricks for an old oncogene

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Myc, a transcription factor commonly deregulated in tumorigenesis, is thought to mediate its diverse cellular effects by altering the expression of specific target genes. However, it has been difficult to gain a precise understanding of how Myc drives cancer because Myc acts rather weakly at many of its target loci, and it has been reported to regulate as many as 10% to 15% of all cellular genes. A new perspective on this issue has been provided by a recent study that revealed Myc can regulate chromatin structure in a global fashion. These findings suggest actions for Myc that extend beyond the traditional concept of a targeted gene regulator.

Original languageEnglish (US)
Pages (from-to)5061-5063
Number of pages3
JournalCancer Research
Volume67
Issue number11
DOIs
StatePublished - Jun 1 2007

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Oncogenes
Regulator Genes
Genes
Chromatin
Carcinogenesis
Transcription Factors
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Myc goes global : New tricks for an old oncogene. / Knoepfler, Paul S.

In: Cancer Research, Vol. 67, No. 11, 01.06.2007, p. 5061-5063.

Research output: Contribution to journalArticle

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