Mutagenesis of the avian erythroblastosis virus erbB coding region: An intact extracellular domain is not required for oncogenic transformation

M. Bassiri, M. L. Privalsky

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Avian erythroblastosis virus (AEV) is an oncogenic retrovirus of birds. The AEV-encoded erbB polypeptide, a transmembrane glycoprotein bearing a N-terminal domain exposed on the surface of virally transformed cells, plays a crucial role in AEV-mediated oncogenesis. We report here a characterization of a mutated form of the AEV erbB protein which lacks over two-thirds of the extracellular region of this oncogenic protein. This mutant v-erbB protein, although lacking the three possible extracellular sites of N-linked protein glycosylation, appears unimpaired in the ability to transform cells to an oncogenic phenotype.

Original languageEnglish (US)
Pages (from-to)525-530
Number of pages6
JournalJournal of Virology
Volume59
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Immunology

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