Abstract
Avian erythroblastosis virus (AEV) is an oncogenic retrovirus of birds. The AEV-encoded erbB polypeptide, a transmembrane glycoprotein bearing a N-terminal domain exposed on the surface of virally transformed cells, plays a crucial role in AEV-mediated oncogenesis. We report here a characterization of a mutated form of the AEV erbB protein which lacks over two-thirds of the extracellular region of this oncogenic protein. This mutant v-erbB protein, although lacking the three possible extracellular sites of N-linked protein glycosylation, appears unimpaired in the ability to transform cells to an oncogenic phenotype.
Original language | English (US) |
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Pages (from-to) | 525-530 |
Number of pages | 6 |
Journal | Journal of Virology |
Volume | 59 |
Issue number | 2 |
State | Published - 1986 |
ASJC Scopus subject areas
- Immunology