Abstract
Avian erythroblastosis virus (AEV) is an oncogenic retrovirus of birds. The AEV-encoded erbB polypeptide, a transmembrane glycoprotein bearing a N-terminal domain exposed on the surface of virally transformed cells, plays a crucial role in AEV-mediated oncogenesis. We report here a characterization of a mutated form of the AEV erbB protein which lacks over two-thirds of the extracellular region of this oncogenic protein. This mutant v-erbB protein, although lacking the three possible extracellular sites of N-linked protein glycosylation, appears unimpaired in the ability to transform cells to an oncogenic phenotype.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 525-530 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 59 |
| Issue number | 2 |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Immunology
Cite this
Mutagenesis of the avian erythroblastosis virus erbB coding region : An intact extracellular domain is not required for oncogenic transformation. / Bassiri, M.; Privalsky, M. L.
In: Journal of Virology, Vol. 59, No. 2, 1986, p. 525-530.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mutagenesis of the avian erythroblastosis virus erbB coding region
T2 - An intact extracellular domain is not required for oncogenic transformation
AU - Bassiri, M.
AU - Privalsky, M. L.
PY - 1986
Y1 - 1986
N2 - Avian erythroblastosis virus (AEV) is an oncogenic retrovirus of birds. The AEV-encoded erbB polypeptide, a transmembrane glycoprotein bearing a N-terminal domain exposed on the surface of virally transformed cells, plays a crucial role in AEV-mediated oncogenesis. We report here a characterization of a mutated form of the AEV erbB protein which lacks over two-thirds of the extracellular region of this oncogenic protein. This mutant v-erbB protein, although lacking the three possible extracellular sites of N-linked protein glycosylation, appears unimpaired in the ability to transform cells to an oncogenic phenotype.
AB - Avian erythroblastosis virus (AEV) is an oncogenic retrovirus of birds. The AEV-encoded erbB polypeptide, a transmembrane glycoprotein bearing a N-terminal domain exposed on the surface of virally transformed cells, plays a crucial role in AEV-mediated oncogenesis. We report here a characterization of a mutated form of the AEV erbB protein which lacks over two-thirds of the extracellular region of this oncogenic protein. This mutant v-erbB protein, although lacking the three possible extracellular sites of N-linked protein glycosylation, appears unimpaired in the ability to transform cells to an oncogenic phenotype.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022531452&partnerID=8YFLogxK
M3 - Article
C2 - 3016316
AN - SCOPUS:0022531452
VL - 59
SP - 525
EP - 530
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 2
ER -