Muscarinic antagonists attenuate dizocilpine-induced hypermotility in mice

Izyaslav P. Lapin, Michael A Rogawski

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Pretreatment of mice with the muscarinic receptor antagonists scopolamine and atropine attenuated the hypermotility (but not the depression of rearing) induced by a low dose of dizocilpine maleate [(+)-MK-801; 0.1 mg/kg, i.p.], a non-competitive NMDA antagonist. In contrast, the muscarinic blockers failed to affect hypermotility induced by equieffective doses of phencyclidine (1 mg/kg, i.p.) or d-amphetamine (2 mg/kg, i.p.). These results suggest differences between the mechanism of behavioral activation produced by dizocilpine and phencyclidine, and demonstrate the potential of muscarinic blockade for diminishing the behavioral toxicity of NMDA antagonists.

Original languageEnglish (US)
JournalLife Sciences
Volume50
Issue number9
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Muscarinic antagonists attenuate dizocilpine-induced hypermotility in mice'. Together they form a unique fingerprint.

Cite this