Murine T-cell hybridomas that produce lymphokine with macrophage-activating factor activity as a constitutive product

Kent L Erickson, Lucienne Cicurel, Eilene Gruys, Isaiah J. Fidler

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We fused concanavalin A-stimulated spleen lymphocytes of C57BL/6N mice with the AKR T-cell lymphoma BW-5147 G1.4. Four hybridomas expressing both Thy-1.1 and Thy-1.2 surface antigen markers characteristic of both parent types were evaluated for the production of various lymphokines. The resulting T-cell hybridoma constitutively produced a lymphokine that activated murine macrophages to the tumoricidal state without the concomitant production of migration inhibition factor, colony-stimulating factor, or interferon.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalCellular Immunology
Volume72
Issue number1
DOIs
StatePublished - Sep 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Fingerprint Dive into the research topics of 'Murine T-cell hybridomas that produce lymphokine with macrophage-activating factor activity as a constitutive product'. Together they form a unique fingerprint.

  • Cite this