Murine NK-cell licensing is reflective of donor MHC-I following allogeneic hematopoietic stem cell transplantation in murine cytomegalovirus responses.

Can M. Sungur, Yajarayma J. Tang-Feldman, Anthony E. Zamora, Maite Alvarez, Claire Pomeroy, William J Murphy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Natural killer (NK) cells express inhibitory receptors with varied binding affinities to specific major histocompatibility complex class I (MHC-I) haplotypes. NK cells can be classified as licensed or unlicensed based on their ability or inability to bind MHC-I, respectively. The role of donor vs host MHC on their development after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not known. Following reciprocal MHC-disparate allogeneic transplants and during de novo NK-cell recovery, depletion of the licensed and not unlicensed population of NK cells as determined by the licensing patterns of donor MHC-I haplotypes, resulted in significantly increased susceptibility to murine cytomegalovirus (MCMV) infection. A corresponding expansion of the licensed Ly49H(+) NK cells occurred with greater interferon γ production by these cells than unlicensed NK cells in the context of donor MHC-I. Thus, NK licensing behavior to MCMV corresponds to the donor, and not recipient, MHC haplotype after allo-HSCT in mice.

Original languageEnglish (US)
Pages (from-to)1518-1521
Number of pages4
JournalBlood
Volume122
Issue number8
DOIs
StatePublished - Aug 22 2013

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Muromegalovirus
Hematopoietic Stem Cell Transplantation
Licensure
Stem cells
Major Histocompatibility Complex
Natural Killer Cells
Transplants
Haplotypes
Interferons
Recovery
Natural Killer Cell Receptors
Aptitude
Cytomegalovirus Infections
Population

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Murine NK-cell licensing is reflective of donor MHC-I following allogeneic hematopoietic stem cell transplantation in murine cytomegalovirus responses. / Sungur, Can M.; Tang-Feldman, Yajarayma J.; Zamora, Anthony E.; Alvarez, Maite; Pomeroy, Claire; Murphy, William J.

In: Blood, Vol. 122, No. 8, 22.08.2013, p. 1518-1521.

Research output: Contribution to journalArticle

Sungur, Can M. ; Tang-Feldman, Yajarayma J. ; Zamora, Anthony E. ; Alvarez, Maite ; Pomeroy, Claire ; Murphy, William J. / Murine NK-cell licensing is reflective of donor MHC-I following allogeneic hematopoietic stem cell transplantation in murine cytomegalovirus responses. In: Blood. 2013 ; Vol. 122, No. 8. pp. 1518-1521.
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