Murine models of autoimmune cholangitis

Yoshiyuki Ueno, Yoko M. Ambrosini, Yuki Moritoki, William M. Ridgway, M. Eric Gershwin

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose of Review: Primary biliary cirrhosis (PBC) is a human autoimmune liver disease whose molecular pathogenesis is poorly understood because of the difficulty in accessing human tissue and the absence of appropriate animal models. Recently, several unique murine models of human PBC have been discovered. These models have great potential for illustrating the cause and the cellular events that lead to biliary-specific damage. The purpose of this review is to summarize recent progress in these models. Recent Findings: The murine models of autoimmune cholangitis include the transforming growth factor beta receptor II (TGF-βRII) dominant-negative (dnTGF-βRII), IL-2 receptor α deleted (IL-2Rα), scurfy, nonobese diabetic (NOD) c3c4, and Ae2 gene-disrupted (Ae2a,b) mice. Recently, we have also established a successful murine model following the immunization with a chemical mimicry of the lipoyl-lysine residue of the E2 component of PDC-E2. Summary: These emerging murine models have greatly enabled researchers to address the pathogenesis of human PBC and to elucidate pathogenic factors. These models will ultimately lead to new therapeutic options for human PBC.

Original languageEnglish (US)
Pages (from-to)274-279
Number of pages6
JournalCurrent Opinion in Gastroenterology
Volume26
Issue number3
DOIs
StatePublished - May 2010

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Cholangitis
Biliary Liver Cirrhosis
Interleukin-2 Receptors
Autoimmune Diseases
Lysine
Liver Diseases
Immunization
Animal Models
Research Personnel
Genes

Keywords

  • CD8 T cells
  • Cytokines
  • Primary biliary cirrhosis
  • Regulatory B cells

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Murine models of autoimmune cholangitis. / Ueno, Yoshiyuki; Ambrosini, Yoko M.; Moritoki, Yuki; Ridgway, William M.; Gershwin, M. Eric.

In: Current Opinion in Gastroenterology, Vol. 26, No. 3, 05.2010, p. 274-279.

Research output: Contribution to journalArticle

Ueno, Y, Ambrosini, YM, Moritoki, Y, Ridgway, WM & Gershwin, ME 2010, 'Murine models of autoimmune cholangitis', Current Opinion in Gastroenterology, vol. 26, no. 3, pp. 274-279. https://doi.org/10.1097/MOG.0b013e32833755aa
Ueno, Yoshiyuki ; Ambrosini, Yoko M. ; Moritoki, Yuki ; Ridgway, William M. ; Gershwin, M. Eric. / Murine models of autoimmune cholangitis. In: Current Opinion in Gastroenterology. 2010 ; Vol. 26, No. 3. pp. 274-279.
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