Murine mammary tumor virus seroepidemiology in balb/cfc3h mice: Correlation with tumor development

Bruce W. Altrock, Robert Cardiff, Phyllis B. Blair

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Serum reactivity to murine mammary tumor virus (MuMTV) was inversely related to mammary tumor risk in 8- to 22-week-old BALB/cfC3H breeding females. Mice at low tumor risk exhibited high-titered serum reactivity to MuMTV (50% end point, ≥1:40 by radioimmunoassay) approximately 3-6 months earlier than did the mice at high tumor risk. Maternal MuMTV antibody levels were correlated with the serum anti-MuMTV reactivity of their neonatal offspring (2 wk of age). Serologic antiviral reactivity in infected mice did not change during periods of pregnancy and lactation. All infected animals had detectable serum MuMTV reactivity by 33 weeks of age. The virus-neutralizing capabilities of some of these sera were tested, Sera from some of the young, low-tumor-risk animals that had MuMTV-precipitat- ing antibodies also had virus-neutralizing activity. Conversely, none of the sera from the high-tumor-risk animals had detectable MuMTV-neutralizing antibodies.—JNCI 1981; 67:163-168.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalJournal of the National Cancer Institute
Volume67
Issue number1
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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