Abstract
A multivariate optical computer has been constructed consisting of a spectrograph, digital micromirror device, and photomultiplier tube that is capable of determining absolute concentrations of individual components of a multivariate spectral model. We present experimental results on ternary mixtures, showing accurate quantification of chemical concentrations based on integrated intensities of fluorescence and Raman spectra measured with a single point detector. We additionally show in simulation that point measurements based on principal component spectra retain the ability to classify cancerous from noncancerous T cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 16950-16962 |
| Number of pages | 13 |
| Journal | Optics Express |
| Volume | 19 |
| Issue number | 18 |
| DOIs | |
| State | Published - Aug 29 2011 |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
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Smith, Z. J., Strombom, S., & Wachsmann-Hogiu, S. (2011). Multivariate optical computing using a digital micromirror device for fluorescence and Raman spectroscopy. Optics Express, 19(18), 16950-16962. https://doi.org/10.1364/OE.19.016950