Multispectral scanning time-resolved fluorescence spectroscopy (TRFS) technique for intravascular diagnosis

Hongtao Xie, Julien Bec, Jing Liu, Yang Sun, Matthew Lam, Diego R. Yankelevich, Laura Marcu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


This study describes a scanning time-resolved fluorescence spectroscopy (TRFS) system designed to continuously acquire fluorescence emission and to reconstruct fluorescence lifetime images (FLIM) from a luminal surface by using a catheter-based optical probe with rotary joint and pull-back device. The ability of the system to temporally and spectrally resolve the fluorescence emission from tissue was validated using standard dyes and tissue phantoms (e.g., ex vivo pig aorta phantom). Current results demonstrate that this system is capable to reliably resolve the fluorescence emission of multiple fluorophores located in the lumen; and suggest its potential for intravascular detection of distinct biochemical features of atherosclerotic plaques.

Original languageEnglish (US)
Pages (from-to)1521-1533
Number of pages13
JournalBiomedical Optics Express
Issue number7
StatePublished - Jul 1 2012

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology


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