Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy

Nopmanee Taechangam, Amir Kol, Boaz Arzi, Dori L. Borjesson

Research output: Contribution to journalReview articlepeer-review

Abstract

Multipotent stromal cells (MSCs) are widely utilized in therapy for their immunomodulatory properties, but their usage in infectious viral diseases is less explored. This review aimed to collate the current novel use of MSCs in virus-associated conditions, including MSC’s susceptibility to virus infection, antiviral properties of MSCs and their effects on cell-based immune response and implementation of MSC therapy in animal models and human clinical trials of viral diseases. Recent discoveries shed lights on MSC’s capability in suppressing viral replication and augmenting clearance through enhancement of antiviral immunity. MSC therapy may maintain a crucial balance between aiding pathogen clearance and suppressing hyperactive immune response. Graphical Abstract: [Figure not available: see fulltext.]

Original languageEnglish (US)
JournalStem Cell Reviews and Reports
DOIs
StateAccepted/In press - 2021

Keywords

  • Antiviral immunity
  • Mesenchymal stem cell
  • Multipotent stromal cells
  • Viral disease
  • Virus interaction

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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