Multiple tumor types appear in a transgenic mouse with the RAS oncogene

Robert Cardiff, A. Leder, A. Kuo, P. K. Pattengale, P. Leder

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

A transgenic mouse strain with the ζ-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here. The predominate mesenchymal tumors were dermal spindle cell tumors, which resembled malignant fibrous histiocytomas found in humans. They were associated with hepatosplenomegaly and developed beneath squamous papillomas. The hepatosplenomegaly was associated with infiltrates of cells that tended toward myelocytic or monocytic differentiation. Other epithelial tumors included keratoacanthomas and squamous cell carcinomas. Squamous cysts, some with squamous cell carcinomas, of the salivary glands and mammary carcinomas were also found. Odontogenic tumors, which sometimes differentiated into ameloblastomas, were one of the more unusual tumor types observed. Other, less frequent tumors were also noted. The tumors described here are a potentially valuable experimental resource that may lead to an understanding of malignant fibrous histiocytoma-like lesions, odontogenic tumors, and tumor progression.

Original languageEnglish (US)
Pages (from-to)1199-1207
Number of pages9
JournalAmerican Journal of Pathology
Volume142
Issue number4
StatePublished - Dec 1 1993

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Oncogenes
Transgenic Mice
Neoplasms
Odontogenic Tumors
Malignant Fibrous Histiocytoma
Squamous Cell Carcinoma
Keratoacanthoma
Ameloblastoma
Glandular and Epithelial Neoplasms
Globins
ras Genes
Papilloma
Salivary Glands
Cysts
Breast Neoplasms
Skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cardiff, R., Leder, A., Kuo, A., Pattengale, P. K., & Leder, P. (1993). Multiple tumor types appear in a transgenic mouse with the RAS oncogene. American Journal of Pathology, 142(4), 1199-1207.

Multiple tumor types appear in a transgenic mouse with the RAS oncogene. / Cardiff, Robert; Leder, A.; Kuo, A.; Pattengale, P. K.; Leder, P.

In: American Journal of Pathology, Vol. 142, No. 4, 01.12.1993, p. 1199-1207.

Research output: Contribution to journalArticle

Cardiff, R, Leder, A, Kuo, A, Pattengale, PK & Leder, P 1993, 'Multiple tumor types appear in a transgenic mouse with the RAS oncogene', American Journal of Pathology, vol. 142, no. 4, pp. 1199-1207.
Cardiff R, Leder A, Kuo A, Pattengale PK, Leder P. Multiple tumor types appear in a transgenic mouse with the RAS oncogene. American Journal of Pathology. 1993 Dec 1;142(4):1199-1207.
Cardiff, Robert ; Leder, A. ; Kuo, A. ; Pattengale, P. K. ; Leder, P. / Multiple tumor types appear in a transgenic mouse with the RAS oncogene. In: American Journal of Pathology. 1993 ; Vol. 142, No. 4. pp. 1199-1207.
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