Abstract
A transgenic mouse strain with the ζ-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here. The predominate mesenchymal tumors were dermal spindle cell tumors, which resembled malignant fibrous histiocytomas found in humans. They were associated with hepatosplenomegaly and developed beneath squamous papillomas. The hepatosplenomegaly was associated with infiltrates of cells that tended toward myelocytic or monocytic differentiation. Other epithelial tumors included keratoacanthomas and squamous cell carcinomas. Squamous cysts, some with squamous cell carcinomas, of the salivary glands and mammary carcinomas were also found. Odontogenic tumors, which sometimes differentiated into ameloblastomas, were one of the more unusual tumor types observed. Other, less frequent tumors were also noted. The tumors described here are a potentially valuable experimental resource that may lead to an understanding of malignant fibrous histiocytoma-like lesions, odontogenic tumors, and tumor progression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1199-1207 |
| Number of pages | 9 |
| Journal | American Journal of Pathology |
| Volume | 142 |
| Issue number | 4 |
| State | Published - Dec 1 1993 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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Multiple tumor types appear in a transgenic mouse with the RAS oncogene. / Cardiff, Robert; Leder, A.; Kuo, A.; Pattengale, P. K.; Leder, P.
In: American Journal of Pathology, Vol. 142, No. 4, 01.12.1993, p. 1199-1207.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple tumor types appear in a transgenic mouse with the RAS oncogene
AU - Cardiff, Robert
AU - Leder, A.
AU - Kuo, A.
AU - Pattengale, P. K.
AU - Leder, P.
PY - 1993/12/1
Y1 - 1993/12/1
N2 - A transgenic mouse strain with the ζ-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here. The predominate mesenchymal tumors were dermal spindle cell tumors, which resembled malignant fibrous histiocytomas found in humans. They were associated with hepatosplenomegaly and developed beneath squamous papillomas. The hepatosplenomegaly was associated with infiltrates of cells that tended toward myelocytic or monocytic differentiation. Other epithelial tumors included keratoacanthomas and squamous cell carcinomas. Squamous cysts, some with squamous cell carcinomas, of the salivary glands and mammary carcinomas were also found. Odontogenic tumors, which sometimes differentiated into ameloblastomas, were one of the more unusual tumor types observed. Other, less frequent tumors were also noted. The tumors described here are a potentially valuable experimental resource that may lead to an understanding of malignant fibrous histiocytoma-like lesions, odontogenic tumors, and tumor progression.
AB - A transgenic mouse strain with the ζ-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here. The predominate mesenchymal tumors were dermal spindle cell tumors, which resembled malignant fibrous histiocytomas found in humans. They were associated with hepatosplenomegaly and developed beneath squamous papillomas. The hepatosplenomegaly was associated with infiltrates of cells that tended toward myelocytic or monocytic differentiation. Other epithelial tumors included keratoacanthomas and squamous cell carcinomas. Squamous cysts, some with squamous cell carcinomas, of the salivary glands and mammary carcinomas were also found. Odontogenic tumors, which sometimes differentiated into ameloblastomas, were one of the more unusual tumor types observed. Other, less frequent tumors were also noted. The tumors described here are a potentially valuable experimental resource that may lead to an understanding of malignant fibrous histiocytoma-like lesions, odontogenic tumors, and tumor progression.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027759287&partnerID=8YFLogxK
M3 - Article
C2 - 8475993
AN - SCOPUS:0027759287
VL - 142
SP - 1199
EP - 1207
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 4
ER -