Multiple tumor types appear in a transgenic mouse with the RAS oncogene

R. D. Cardiff, A. Leder, A. Kuo, P. K. Pattengale, P. Leder

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


A transgenic mouse strain with the ζ-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here. The predominate mesenchymal tumors were dermal spindle cell tumors, which resembled malignant fibrous histiocytomas found in humans. They were associated with hepatosplenomegaly and developed beneath squamous papillomas. The hepatosplenomegaly was associated with infiltrates of cells that tended toward myelocytic or monocytic differentiation. Other epithelial tumors included keratoacanthomas and squamous cell carcinomas. Squamous cysts, some with squamous cell carcinomas, of the salivary glands and mammary carcinomas were also found. Odontogenic tumors, which sometimes differentiated into ameloblastomas, were one of the more unusual tumor types observed. Other, less frequent tumors were also noted. The tumors described here are a potentially valuable experimental resource that may lead to an understanding of malignant fibrous histiocytoma-like lesions, odontogenic tumors, and tumor progression.

Original languageEnglish (US)
Pages (from-to)1199-1207
Number of pages9
JournalAmerican Journal of Pathology
Issue number4
StatePublished - Dec 1 1993

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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