Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma

Robert C. Rennert, Achal S. Achrol, Michael Januszyk, Suzana A. Kahn, Tiffany T. Liu, Yi Liu, Debashis Sahoo, Melanie Rodrigues, Zeshaan N. Maan, Victor W. Wong, Samuel H. Cheshier, Steven D. Chang, Gary K. Steinberg, Griffith R. Harsh, Geoffrey C. Gurtner

Research output: Contribution to journalArticlepeer-review

Abstract

Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. In this work, we use single-cell microfluidic profiling to test the fundamental hypothesis that multiple subsets of brain tumor-initiating cells coexist, and underlie human glioblastoma molecular heterogeneity.

Original languageEnglish (US)
Pages (from-to)1702-1707
Number of pages6
JournalStem Cells
Volume34
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Keywords

  • Brain tumor initiating cells
  • Glioblastoma
  • Microfluidics
  • Molecular heterogeneity

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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