Multiple sclerosis vs acute disseminated encephalomyelitis in childhood

Steven David Brass, Zografos Caramanos, Carlos Santos, Marie Emmanuelle Dilenge, Yves Lapierre, Bernard Rosenblatt

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The initial presenting clinical and laboratory findings of either acute disseminated encephalomyelitis or the first attack of multiple sclerosis in the pediatric population were compared and contrasted. A retrospective review of the medical records was conducted of all children younger than 17 years who presented with either the diagnosis of acute disseminated encephalomyelitis or multiple sclerosis between 1987 and 2001. Seventeen cases of clinically definite multiple sclerosis (seven female, mean age 12.4 ± 4.5 years) and seven cases of acute disseminated encephalomyelitis (three female; mean age 8.7 ± 3.8 years) were reviewed. Systemic and nonfocal neurologic symptoms were more commonly evident in acute disseminated encephalomyelitis than in multiple sclerosis: fever (43% vs 6%), headache (57% vs 24%), fatigue (71% vs 29%), vomiting (57% vs 0%), and encephalopathy (71% vs 6%). In multiple sclerosis patients, T2-weighted white matter magnetic resonance imaging lesions were more commonly located in the corpus callosum (64% vs 17%) and the periventricular area (91% vs 50%) compared with those in patients with acute disseminated encephalomyelitis. These results suggest that acute disseminated encephalomyelitis and multiple sclerosis can be differentiated to some degree according to clinical and radiologic data at initial presentation, which is important because the long-term prognosis for childhood multiple sclerosis appears to be less favorable.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalPediatric Neurology
Volume29
Issue number3
DOIs
StatePublished - Sep 2003
Externally publishedYes

Fingerprint

Acute Disseminated Encephalomyelitis
Multiple Sclerosis
Corpus Callosum
Brain Diseases
Neurologic Manifestations
Vomiting
Medical Records
Fatigue
Headache
Fever
Magnetic Resonance Imaging
Pediatrics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Brass, S. D., Caramanos, Z., Santos, C., Dilenge, M. E., Lapierre, Y., & Rosenblatt, B. (2003). Multiple sclerosis vs acute disseminated encephalomyelitis in childhood. Pediatric Neurology, 29(3), 227-231. https://doi.org/10.1016/S0887-8994(03)00235-2

Multiple sclerosis vs acute disseminated encephalomyelitis in childhood. / Brass, Steven David; Caramanos, Zografos; Santos, Carlos; Dilenge, Marie Emmanuelle; Lapierre, Yves; Rosenblatt, Bernard.

In: Pediatric Neurology, Vol. 29, No. 3, 09.2003, p. 227-231.

Research output: Contribution to journalArticle

Brass, SD, Caramanos, Z, Santos, C, Dilenge, ME, Lapierre, Y & Rosenblatt, B 2003, 'Multiple sclerosis vs acute disseminated encephalomyelitis in childhood', Pediatric Neurology, vol. 29, no. 3, pp. 227-231. https://doi.org/10.1016/S0887-8994(03)00235-2
Brass SD, Caramanos Z, Santos C, Dilenge ME, Lapierre Y, Rosenblatt B. Multiple sclerosis vs acute disseminated encephalomyelitis in childhood. Pediatric Neurology. 2003 Sep;29(3):227-231. https://doi.org/10.1016/S0887-8994(03)00235-2
Brass, Steven David ; Caramanos, Zografos ; Santos, Carlos ; Dilenge, Marie Emmanuelle ; Lapierre, Yves ; Rosenblatt, Bernard. / Multiple sclerosis vs acute disseminated encephalomyelitis in childhood. In: Pediatric Neurology. 2003 ; Vol. 29, No. 3. pp. 227-231.
@article{102ab55f4fd147929c6c8753afb0727e,
title = "Multiple sclerosis vs acute disseminated encephalomyelitis in childhood",
abstract = "The initial presenting clinical and laboratory findings of either acute disseminated encephalomyelitis or the first attack of multiple sclerosis in the pediatric population were compared and contrasted. A retrospective review of the medical records was conducted of all children younger than 17 years who presented with either the diagnosis of acute disseminated encephalomyelitis or multiple sclerosis between 1987 and 2001. Seventeen cases of clinically definite multiple sclerosis (seven female, mean age 12.4 ± 4.5 years) and seven cases of acute disseminated encephalomyelitis (three female; mean age 8.7 ± 3.8 years) were reviewed. Systemic and nonfocal neurologic symptoms were more commonly evident in acute disseminated encephalomyelitis than in multiple sclerosis: fever (43{\%} vs 6{\%}), headache (57{\%} vs 24{\%}), fatigue (71{\%} vs 29{\%}), vomiting (57{\%} vs 0{\%}), and encephalopathy (71{\%} vs 6{\%}). In multiple sclerosis patients, T2-weighted white matter magnetic resonance imaging lesions were more commonly located in the corpus callosum (64{\%} vs 17{\%}) and the periventricular area (91{\%} vs 50{\%}) compared with those in patients with acute disseminated encephalomyelitis. These results suggest that acute disseminated encephalomyelitis and multiple sclerosis can be differentiated to some degree according to clinical and radiologic data at initial presentation, which is important because the long-term prognosis for childhood multiple sclerosis appears to be less favorable.",
author = "Brass, {Steven David} and Zografos Caramanos and Carlos Santos and Dilenge, {Marie Emmanuelle} and Yves Lapierre and Bernard Rosenblatt",
year = "2003",
month = "9",
doi = "10.1016/S0887-8994(03)00235-2",
language = "English (US)",
volume = "29",
pages = "227--231",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Multiple sclerosis vs acute disseminated encephalomyelitis in childhood

AU - Brass, Steven David

AU - Caramanos, Zografos

AU - Santos, Carlos

AU - Dilenge, Marie Emmanuelle

AU - Lapierre, Yves

AU - Rosenblatt, Bernard

PY - 2003/9

Y1 - 2003/9

N2 - The initial presenting clinical and laboratory findings of either acute disseminated encephalomyelitis or the first attack of multiple sclerosis in the pediatric population were compared and contrasted. A retrospective review of the medical records was conducted of all children younger than 17 years who presented with either the diagnosis of acute disseminated encephalomyelitis or multiple sclerosis between 1987 and 2001. Seventeen cases of clinically definite multiple sclerosis (seven female, mean age 12.4 ± 4.5 years) and seven cases of acute disseminated encephalomyelitis (three female; mean age 8.7 ± 3.8 years) were reviewed. Systemic and nonfocal neurologic symptoms were more commonly evident in acute disseminated encephalomyelitis than in multiple sclerosis: fever (43% vs 6%), headache (57% vs 24%), fatigue (71% vs 29%), vomiting (57% vs 0%), and encephalopathy (71% vs 6%). In multiple sclerosis patients, T2-weighted white matter magnetic resonance imaging lesions were more commonly located in the corpus callosum (64% vs 17%) and the periventricular area (91% vs 50%) compared with those in patients with acute disseminated encephalomyelitis. These results suggest that acute disseminated encephalomyelitis and multiple sclerosis can be differentiated to some degree according to clinical and radiologic data at initial presentation, which is important because the long-term prognosis for childhood multiple sclerosis appears to be less favorable.

AB - The initial presenting clinical and laboratory findings of either acute disseminated encephalomyelitis or the first attack of multiple sclerosis in the pediatric population were compared and contrasted. A retrospective review of the medical records was conducted of all children younger than 17 years who presented with either the diagnosis of acute disseminated encephalomyelitis or multiple sclerosis between 1987 and 2001. Seventeen cases of clinically definite multiple sclerosis (seven female, mean age 12.4 ± 4.5 years) and seven cases of acute disseminated encephalomyelitis (three female; mean age 8.7 ± 3.8 years) were reviewed. Systemic and nonfocal neurologic symptoms were more commonly evident in acute disseminated encephalomyelitis than in multiple sclerosis: fever (43% vs 6%), headache (57% vs 24%), fatigue (71% vs 29%), vomiting (57% vs 0%), and encephalopathy (71% vs 6%). In multiple sclerosis patients, T2-weighted white matter magnetic resonance imaging lesions were more commonly located in the corpus callosum (64% vs 17%) and the periventricular area (91% vs 50%) compared with those in patients with acute disseminated encephalomyelitis. These results suggest that acute disseminated encephalomyelitis and multiple sclerosis can be differentiated to some degree according to clinical and radiologic data at initial presentation, which is important because the long-term prognosis for childhood multiple sclerosis appears to be less favorable.

UR - http://www.scopus.com/inward/record.url?scp=0242558184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242558184&partnerID=8YFLogxK

U2 - 10.1016/S0887-8994(03)00235-2

DO - 10.1016/S0887-8994(03)00235-2

M3 - Article

VL - 29

SP - 227

EP - 231

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

IS - 3

ER -