Multiple sclerosis: Activated cells in cerebrospinal fluid in acute exacerbations

A. Noronha, David P Richman, B. G W Arnason

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Cerebrospinal fluid (CSF) lymphocytes from three young patients undergoing acute exacerbations of multiple sclerosis were studied by flow cytometry. Using a new method that simultaneously measures cell-surface antigens and the cell-cycle phase, we determined that the CSF lymphocytes in these patients were activated. The majority of the activated cells expressed the OKT4 phenotype, while very few expressed the OKT8 phenotype.

Original languageEnglish (US)
Pages (from-to)722-725
Number of pages4
JournalAnnals of Neurology
Issue number6
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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