Multiple sclerosis: Activated cells in cerebrospinal fluid in acute exacerbations

A. Noronha; David P Richman; B. G W Arnason

Multiple sclerosis: Activated cells in cerebrospinal fluid in acute exacerbations

A. Noronha, David P Richman, B. G W Arnason

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebrospinal fluid (CSF) lymphocytes from three young patients undergoing acute exacerbations of multiple sclerosis were studied by flow cytometry. Using a new method that simultaneously measures cell-surface antigens and the cell-cycle phase, we determined that the CSF lymphocytes in these patients were activated. The majority of the activated cells expressed the OKT4 phenotype, while very few expressed the OKT8 phenotype.

Original language	English (US)
Pages (from-to)	722-725
Number of pages	4
Journal	Annals of Neurology
Volume	18
Issue number	6
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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title = "Multiple sclerosis: Activated cells in cerebrospinal fluid in acute exacerbations",

abstract = "Cerebrospinal fluid (CSF) lymphocytes from three young patients undergoing acute exacerbations of multiple sclerosis were studied by flow cytometry. Using a new method that simultaneously measures cell-surface antigens and the cell-cycle phase, we determined that the CSF lymphocytes in these patients were activated. The majority of the activated cells expressed the OKT4 phenotype, while very few expressed the OKT8 phenotype.",

author = "A. Noronha and Richman, {David P} and Arnason, {B. G W}",

year = "1985",

language = "English (US)",

volume = "18",

pages = "722--725",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

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T2 - Activated cells in cerebrospinal fluid in acute exacerbations

AU - Noronha, A.

AU - Richman, David P

AU - Arnason, B. G W

PY - 1985

Y1 - 1985

N2 - Cerebrospinal fluid (CSF) lymphocytes from three young patients undergoing acute exacerbations of multiple sclerosis were studied by flow cytometry. Using a new method that simultaneously measures cell-surface antigens and the cell-cycle phase, we determined that the CSF lymphocytes in these patients were activated. The majority of the activated cells expressed the OKT4 phenotype, while very few expressed the OKT8 phenotype.

AB - Cerebrospinal fluid (CSF) lymphocytes from three young patients undergoing acute exacerbations of multiple sclerosis were studied by flow cytometry. Using a new method that simultaneously measures cell-surface antigens and the cell-cycle phase, we determined that the CSF lymphocytes in these patients were activated. The majority of the activated cells expressed the OKT4 phenotype, while very few expressed the OKT8 phenotype.

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M3 - Article

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AN - SCOPUS:0022189610

VL - 18

SP - 722

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JO - Annals of Neurology

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