Multiple Sclerosis

Steven D. Brass, Howard L. Weiner, David A. Hafler

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter begins with the history of multiple sclerosis (MS), followed by its clinical feature. The symptoms and signs of MS are variable as the disease can affect the CNS anywhere. Demyelinating lesions may develop at any site along myelinated CNS white matter tracts. The most common symptoms and signs involve alteration or loss of sensation due to involvement of spinothalamic or posterior column fibers, visual loss from optic neuritis, limb weakness and spasticity related to disruption of corticospinal tracts, tremors, and incoordination of gait or limbs, largely related to cerebellar or spinocerebellar fiber involvement. MS may be divided into four clinical categories: clinically isolated syndrome (CIS), relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), and primary progressive multiple sclerosis (PPMS). Most patients change from a CIS to RRMS and then gradually become SPMS. Furthermore, the chapter focuses on the immunologic markers of MS. The CSF of patients with MS typically shows normal glucose, a few lymphocytes, normal to mildly elevated total protein, and oligoclonal immunoglobulin bands (OCBs). The chapter also discusses pathology, epidemiology, animal models, and treatments of MS.

Original languageEnglish (US)
Title of host publicationThe Autoimmune Diseases
PublisherElsevier Inc.
Pages615-632
Number of pages18
ISBN (Print)9780125959612
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Multiple Sclerosis
Chronic Progressive Multiple Sclerosis
Oligoclonal Bands
Relapsing-Remitting Multiple Sclerosis
Signs and Symptoms
Extremities
Optic Neuritis
Pyramidal Tracts
Tremor
Ataxia
Gait
Epidemiology
Animal Models
Biomarkers
History
Lymphocytes
Pathology
Glucose
Proteins

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Brass, S. D., Weiner, H. L., & Hafler, D. A. (2006). Multiple Sclerosis. In The Autoimmune Diseases (pp. 615-632). Elsevier Inc.. https://doi.org/10.1016/B978-012595961-2/50049-4

Multiple Sclerosis. / Brass, Steven D.; Weiner, Howard L.; Hafler, David A.

The Autoimmune Diseases. Elsevier Inc., 2006. p. 615-632.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brass, SD, Weiner, HL & Hafler, DA 2006, Multiple Sclerosis. in The Autoimmune Diseases. Elsevier Inc., pp. 615-632. https://doi.org/10.1016/B978-012595961-2/50049-4
Brass SD, Weiner HL, Hafler DA. Multiple Sclerosis. In The Autoimmune Diseases. Elsevier Inc. 2006. p. 615-632 https://doi.org/10.1016/B978-012595961-2/50049-4
Brass, Steven D. ; Weiner, Howard L. ; Hafler, David A. / Multiple Sclerosis. The Autoimmune Diseases. Elsevier Inc., 2006. pp. 615-632
@inbook{c32b723c2c33488da6909ec972793cd8,
title = "Multiple Sclerosis",
abstract = "This chapter begins with the history of multiple sclerosis (MS), followed by its clinical feature. The symptoms and signs of MS are variable as the disease can affect the CNS anywhere. Demyelinating lesions may develop at any site along myelinated CNS white matter tracts. The most common symptoms and signs involve alteration or loss of sensation due to involvement of spinothalamic or posterior column fibers, visual loss from optic neuritis, limb weakness and spasticity related to disruption of corticospinal tracts, tremors, and incoordination of gait or limbs, largely related to cerebellar or spinocerebellar fiber involvement. MS may be divided into four clinical categories: clinically isolated syndrome (CIS), relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), and primary progressive multiple sclerosis (PPMS). Most patients change from a CIS to RRMS and then gradually become SPMS. Furthermore, the chapter focuses on the immunologic markers of MS. The CSF of patients with MS typically shows normal glucose, a few lymphocytes, normal to mildly elevated total protein, and oligoclonal immunoglobulin bands (OCBs). The chapter also discusses pathology, epidemiology, animal models, and treatments of MS.",
author = "Brass, {Steven D.} and Weiner, {Howard L.} and Hafler, {David A.}",
year = "2006",
doi = "10.1016/B978-012595961-2/50049-4",
language = "English (US)",
isbn = "9780125959612",
pages = "615--632",
booktitle = "The Autoimmune Diseases",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Multiple Sclerosis

AU - Brass, Steven D.

AU - Weiner, Howard L.

AU - Hafler, David A.

PY - 2006

Y1 - 2006

N2 - This chapter begins with the history of multiple sclerosis (MS), followed by its clinical feature. The symptoms and signs of MS are variable as the disease can affect the CNS anywhere. Demyelinating lesions may develop at any site along myelinated CNS white matter tracts. The most common symptoms and signs involve alteration or loss of sensation due to involvement of spinothalamic or posterior column fibers, visual loss from optic neuritis, limb weakness and spasticity related to disruption of corticospinal tracts, tremors, and incoordination of gait or limbs, largely related to cerebellar or spinocerebellar fiber involvement. MS may be divided into four clinical categories: clinically isolated syndrome (CIS), relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), and primary progressive multiple sclerosis (PPMS). Most patients change from a CIS to RRMS and then gradually become SPMS. Furthermore, the chapter focuses on the immunologic markers of MS. The CSF of patients with MS typically shows normal glucose, a few lymphocytes, normal to mildly elevated total protein, and oligoclonal immunoglobulin bands (OCBs). The chapter also discusses pathology, epidemiology, animal models, and treatments of MS.

AB - This chapter begins with the history of multiple sclerosis (MS), followed by its clinical feature. The symptoms and signs of MS are variable as the disease can affect the CNS anywhere. Demyelinating lesions may develop at any site along myelinated CNS white matter tracts. The most common symptoms and signs involve alteration or loss of sensation due to involvement of spinothalamic or posterior column fibers, visual loss from optic neuritis, limb weakness and spasticity related to disruption of corticospinal tracts, tremors, and incoordination of gait or limbs, largely related to cerebellar or spinocerebellar fiber involvement. MS may be divided into four clinical categories: clinically isolated syndrome (CIS), relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), and primary progressive multiple sclerosis (PPMS). Most patients change from a CIS to RRMS and then gradually become SPMS. Furthermore, the chapter focuses on the immunologic markers of MS. The CSF of patients with MS typically shows normal glucose, a few lymphocytes, normal to mildly elevated total protein, and oligoclonal immunoglobulin bands (OCBs). The chapter also discusses pathology, epidemiology, animal models, and treatments of MS.

UR - http://www.scopus.com/inward/record.url?scp=45949111636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45949111636&partnerID=8YFLogxK

U2 - 10.1016/B978-012595961-2/50049-4

DO - 10.1016/B978-012595961-2/50049-4

M3 - Chapter

SN - 9780125959612

SP - 615

EP - 632

BT - The Autoimmune Diseases

PB - Elsevier Inc.

ER -