Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

Stacy L. Musone, Kimberly E. Taylor, Timothy T. Lu, Joanne Nititham, Ricardo C. Ferreira, Ward Ortmann, Nataliya Shifrin, Michelle A. Petri, M. Ilyas Kamboh, Susan Manzi, Michael F Seldin, Peter K. Gregersen, Timothy W. Behrens, Averil Ma, Pui Yan Kwok, Lindsey A. Criswell

Research output: Contribution to journalArticle

316 Scopus citations

Abstract

The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-κB-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between A20 and the etiology of SLE.

Original languageEnglish (US)
Pages (from-to)1062-1064
Number of pages3
JournalNature Genetics
Volume40
Issue number9
DOIs
StatePublished - Sep 2008

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    Musone, S. L., Taylor, K. E., Lu, T. T., Nititham, J., Ferreira, R. C., Ortmann, W., Shifrin, N., Petri, M. A., Ilyas Kamboh, M., Manzi, S., Seldin, M. F., Gregersen, P. K., Behrens, T. W., Ma, A., Kwok, P. Y., & Criswell, L. A. (2008). Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nature Genetics, 40(9), 1062-1064. https://doi.org/10.1038/ng.202