Multiple pathways controlling acid secretion

Kevin C K Lloyd, A. H. Soll

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A simple balance exists between factors that promote ulcer disease (e.g., acid and pepsin secretion) and factors that protect the stomach from ulcer disease (e.g., mucosal defense mechanisms). These factors are regulated and control the integrity of the gastric mucosa. Some of the newest discoveries in the area of regulation of acid secretion are related to the cellular localization of physiologically relevant receptors for acid secretagogues and acid inhibitors. The ability to isolate and culture histamine-containing ECL cells and somatostatin-containing 'D' cells, and the ability to clone genes encoding for specific receptors has greatly enhanced our understanding of the physiological role and the regulation of various cell types within the gastric mucosa.

Original languageEnglish (US)
Pages (from-to)77-79
Number of pages3
JournalJournal of Gastroenterology
Issue numberSUPPL. 7
StatePublished - 1994


  • Cell culture
  • Gastrin
  • Histamine
  • Muscarinic agonists

ASJC Scopus subject areas

  • Gastroenterology


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