Multiple organ failure (MOF) after severe trauma - A sheep model

H. C. Pape, M. Grotz, D. Remmers, A. Dwenger, R. Vaske, David H Wisner, H. Tscherne

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objective: To perform a reproducible long-term (10 days) large animal model of multiple systems organ failure without necessity of a continuous stimulus. Design: Adult female merino sheep submitted to a 5-day stimulation period followed by a 5-day observation period. Day 1: Hemorrhagic shock was combined with a traumatic surgical insult (reamed intramedullary femoral nailing), followed by serial administrations every 12 h for 5 days of a combination of endotoxin and zymosan activated plasma. Organ function was followed for 5 further days. Results: Cardiac index increased significantly during the study (day 1: 491 ± 8 mm Hg; day 10: 427 ± 20, p < 0.05). Liver function was impaired and bilirubin levels increased significantly (day 1: 2.9 ± 0.3 μmol/l; day 10: 7.2 ± 0.9; p < 0.05). Creatinine clearance decreased initially (day 1: 54 ± 7 ml/min), increased to a peak on day 2 (104 ± 27), and then deteriorated again (day 10: 53 ± 18). Conclusion: This new large animal model of trauma-induced MOF is reproducible and may be suitable for the study of new therapeutic approaches to therapy.

Original languageEnglish (US)
Pages (from-to)590-598
Number of pages9
JournalIntensive Care Medicine
Issue number6
StatePublished - 1998


  • Endotoxin
  • Intramedullary femoral nailing
  • Large animal model
  • Multiple organ failure
  • Zymosan activated plasma

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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