Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure

David J. Ciesla, Ernest E. Moore, Jeffrey L. Johnson, Angela Sauaia, Clay C. Cothren, John B. Moore, Jon M. Burch, Donald E. Fry, Basil A. Pruitt, David H. Wisner

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Hypothesis: Multiple organ dysfunction (MOD) within 48 hours of injury is a reversible physiologic response to tissue injury and resuscitation. Design: A prospective 10-year inception cohort study ending September 2003. Setting: Regional academic level I trauma center. Patients: One thousand two hundred seventy-seven consecutive trauma patients at risk for postinjury multiple organ failure (MOF). Inclusion criteria were being 16 years and older, being admitted to the trauma intensive care unit, having an Injury Severity Score higher than 15, and surviving more than 48 hours after injury. Isolated head injuries were excluded. Interventions: None. Main Outcome Measures: Development of postinjury MOD as defined by a Denver MOF score of 4 or higher within 48 hours of injury and MOF as defined by a Denver MOF score of 4 or higher more than 48 hours after injury. Results: Postinjury MOD and MOF were diagnosed in 209 (16%) and 300 (23%) patients, respectively. Age, Injury Severity Score, and 12-hour blood transfusion requirements were significantly higher among patients who developed MOD and MOF. Of the 209 patients who developed MOD, 134 (64%) progressively developed MOF while 75 (36%) had MOD resolve within 48 hours. Conclusion: Multiple organ dysfunction during resuscitation is a reversible response to severe injury and often resolves during the resuscitation period.

Original languageEnglish (US)
Pages (from-to)590-595
Number of pages6
JournalArchives of Surgery
Volume139
Issue number6
DOIs
StatePublished - Jun 2004

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Multiple Organ Failure
Resuscitation
Wounds and Injuries
Organ Dysfunction Scores
Injury Severity Score
Trauma Centers
Craniocerebral Trauma
Blood Transfusion
Intensive Care Units
Cohort Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Surgery

Cite this

Ciesla, D. J., Moore, E. E., Johnson, J. L., Sauaia, A., Cothren, C. C., Moore, J. B., ... Wisner, D. H. (2004). Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure. Archives of Surgery, 139(6), 590-595. https://doi.org/10.1001/archsurg.139.6.590

Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure. / Ciesla, David J.; Moore, Ernest E.; Johnson, Jeffrey L.; Sauaia, Angela; Cothren, Clay C.; Moore, John B.; Burch, Jon M.; Fry, Donald E.; Pruitt, Basil A.; Wisner, David H.

In: Archives of Surgery, Vol. 139, No. 6, 06.2004, p. 590-595.

Research output: Contribution to journalArticle

Ciesla, DJ, Moore, EE, Johnson, JL, Sauaia, A, Cothren, CC, Moore, JB, Burch, JM, Fry, DE, Pruitt, BA & Wisner, DH 2004, 'Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure', Archives of Surgery, vol. 139, no. 6, pp. 590-595. https://doi.org/10.1001/archsurg.139.6.590
Ciesla DJ, Moore EE, Johnson JL, Sauaia A, Cothren CC, Moore JB et al. Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure. Archives of Surgery. 2004 Jun;139(6):590-595. https://doi.org/10.1001/archsurg.139.6.590
Ciesla, David J. ; Moore, Ernest E. ; Johnson, Jeffrey L. ; Sauaia, Angela ; Cothren, Clay C. ; Moore, John B. ; Burch, Jon M. ; Fry, Donald E. ; Pruitt, Basil A. ; Wisner, David H. / Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure. In: Archives of Surgery. 2004 ; Vol. 139, No. 6. pp. 590-595.
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