Multiple modes of cytoplasmic dynein regulation

Richard B. Vallee, Richard Mckenney, Kassandra M. Ori-Mckenney

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations


In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high-and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalNature Cell Biology
Issue number3
StatePublished - Mar 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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