Multiple modes of cytoplasmic dynein regulation

Richard B. Vallee, Richard Mckenney, Kassandra M. Ori-Mckenney

Research output: Contribution to journalReview article

114 Citations (Scopus)

Abstract

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high-and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalNature Cell Biology
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Fingerprint

Cytoplasmic Dyneins
Allosteric Regulation
Dyneins
Motor Activity

ASJC Scopus subject areas

  • Cell Biology

Cite this

Multiple modes of cytoplasmic dynein regulation. / Vallee, Richard B.; Mckenney, Richard; Ori-Mckenney, Kassandra M.

In: Nature Cell Biology, Vol. 14, No. 3, 01.03.2012, p. 224-230.

Research output: Contribution to journalReview article

Vallee, Richard B. ; Mckenney, Richard ; Ori-Mckenney, Kassandra M. / Multiple modes of cytoplasmic dynein regulation. In: Nature Cell Biology. 2012 ; Vol. 14, No. 3. pp. 224-230.
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