Multiple modes of cytoplasmic dynein regulation

Richard B. Vallee, Richard Mckenney, Kassandra M. Ori-Mckenney

Research output: Contribution to journalReview article

114 Scopus citations

Abstract

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high-and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalNature Cell Biology
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology

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