Multiple modes of cytoplasmic dynein regulation

Richard B. Vallee; Richard Mckenney; Kassandra M. Ori-Mckenney

doi:10.1038/ncb2420

Multiple modes of cytoplasmic dynein regulation

Richard B. Vallee, Richard Mckenney, Kassandra M. Ori-Mckenney

Research output: Contribution to journal › Review article › peer-review

122 Scopus citations

Abstract

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high-and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

Original language	English (US)
Pages (from-to)	224-230
Number of pages	7
Journal	Nature Cell Biology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1038/ncb2420
State	Published - Mar 1 2012
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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title = "Multiple modes of cytoplasmic dynein regulation",

abstract = "In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high-and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.",

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