Abstract
In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high-and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 224-230 |
| Number of pages | 7 |
| Journal | Nature Cell Biology |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Multiple modes of cytoplasmic dynein regulation. / Vallee, Richard B.; Mckenney, Richard; Ori-Mckenney, Kassandra M.
In: Nature Cell Biology, Vol. 14, No. 3, 01.03.2012, p. 224-230.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Multiple modes of cytoplasmic dynein regulation
AU - Vallee, Richard B.
AU - Mckenney, Richard
AU - Ori-Mckenney, Kassandra M.
PY - 2012/3/1
Y1 - 2012/3/1
N2 - In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high-and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.
AB - In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high-and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.
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UR - http://www.scopus.com/inward/citedby.url?scp=84857717466&partnerID=8YFLogxK
U2 - 10.1038/ncb2420
DO - 10.1038/ncb2420
M3 - Review article
C2 - 22373868
AN - SCOPUS:84857717466
VL - 14
SP - 224
EP - 230
JO - Nature Cell Biology
JF - Nature Cell Biology
SN - 1465-7392
IS - 3
ER -