Multiple keukemic clones in acute leukemia of childhood

H. G. Morse; Jonathan M Ducore; T. Hays; D. Peakman; A. Robinson

doi:10.1007/BF00272187

Multiple keukemic clones in acute leukemia of childhood

H. G. Morse, Jonathan M Ducore, T. Hays, D. Peakman, A. Robinson

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Two abnormal karyotypes representing clonal populations have been demonstrated in three patients in the early stage of acute leukemia. The karyotypes were apparently unrelated in one patient, while in the other two, a relationship was conjectured. Both clones were present before therapy in two patients. Although a clone resistant to therapy was associated with relapse in one case, in two cases a clone has persisted in the lymphocyte culture during drug treatment with the patients in remission.

Original language	English (US)
Pages (from-to)	269-278
Number of pages	10
Journal	Human Genetics
Volume	40
Issue number	3
DOIs	https://doi.org/10.1007/BF00272187
State	Published - Jan 1978
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)
Genetics

Access to Document

10.1007/BF00272187

Fingerprint Dive into the research topics of 'Multiple keukemic clones in acute leukemia of childhood'. Together they form a unique fingerprint.

Cite this

@article{a048b8bfd06e462580e3e5311f961719,

title = "Multiple keukemic clones in acute leukemia of childhood",

abstract = "Two abnormal karyotypes representing clonal populations have been demonstrated in three patients in the early stage of acute leukemia. The karyotypes were apparently unrelated in one patient, while in the other two, a relationship was conjectured. Both clones were present before therapy in two patients. Although a clone resistant to therapy was associated with relapse in one case, in two cases a clone has persisted in the lymphocyte culture during drug treatment with the patients in remission.",

author = "Morse, {H. G.} and Ducore, {Jonathan M} and T. Hays and D. Peakman and A. Robinson",

year = "1978",

month = jan,

doi = "10.1007/BF00272187",

language = "English (US)",

volume = "40",

pages = "269--278",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - Multiple keukemic clones in acute leukemia of childhood

AU - Morse, H. G.

AU - Ducore, Jonathan M

AU - Hays, T.

AU - Peakman, D.

AU - Robinson, A.

PY - 1978/1

Y1 - 1978/1

N2 - Two abnormal karyotypes representing clonal populations have been demonstrated in three patients in the early stage of acute leukemia. The karyotypes were apparently unrelated in one patient, while in the other two, a relationship was conjectured. Both clones were present before therapy in two patients. Although a clone resistant to therapy was associated with relapse in one case, in two cases a clone has persisted in the lymphocyte culture during drug treatment with the patients in remission.

AB - Two abnormal karyotypes representing clonal populations have been demonstrated in three patients in the early stage of acute leukemia. The karyotypes were apparently unrelated in one patient, while in the other two, a relationship was conjectured. Both clones were present before therapy in two patients. Although a clone resistant to therapy was associated with relapse in one case, in two cases a clone has persisted in the lymphocyte culture during drug treatment with the patients in remission.

UR - http://www.scopus.com/inward/record.url?scp=0017891082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017891082&partnerID=8YFLogxK

U2 - 10.1007/BF00272187

DO - 10.1007/BF00272187

M3 - Article

C2 - 273006

AN - SCOPUS:0017891082

VL - 40

SP - 269

EP - 278

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 3

ER -