Multiple keukemic clones in acute leukemia of childhood

H. G. Morse; Jonathan M Ducore; T. Hays; D. Peakman; A. Robinson

doi:10.1007/BF00272187

Multiple keukemic clones in acute leukemia of childhood

H. G. Morse, Jonathan M Ducore, T. Hays, D. Peakman, A. Robinson

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

Two abnormal karyotypes representing clonal populations have been demonstrated in three patients in the early stage of acute leukemia. The karyotypes were apparently unrelated in one patient, while in the other two, a relationship was conjectured. Both clones were present before therapy in two patients. Although a clone resistant to therapy was associated with relapse in one case, in two cases a clone has persisted in the lymphocyte culture during drug treatment with the patients in remission.

Original language	English (US)
Pages (from-to)	269-278
Number of pages	10
Journal	Human Genetics
Volume	40
Issue number	3
DOIs	https://doi.org/10.1007/BF00272187
State	Published - Jan 1978
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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Morse, H. G., Ducore, J. M., Hays, T., Peakman, D., & Robinson, A. (1978). Multiple keukemic clones in acute leukemia of childhood. Human Genetics, 40(3), 269-278. https://doi.org/10.1007/BF00272187

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abstract = "Two abnormal karyotypes representing clonal populations have been demonstrated in three patients in the early stage of acute leukemia. The karyotypes were apparently unrelated in one patient, while in the other two, a relationship was conjectured. Both clones were present before therapy in two patients. Although a clone resistant to therapy was associated with relapse in one case, in two cases a clone has persisted in the lymphocyte culture during drug treatment with the patients in remission.",

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