Multiple keukemic clones in acute leukemia of childhood

H. G. Morse, Jonathan M Ducore, T. Hays, D. Peakman, A. Robinson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Two abnormal karyotypes representing clonal populations have been demonstrated in three patients in the early stage of acute leukemia. The karyotypes were apparently unrelated in one patient, while in the other two, a relationship was conjectured. Both clones were present before therapy in two patients. Although a clone resistant to therapy was associated with relapse in one case, in two cases a clone has persisted in the lymphocyte culture during drug treatment with the patients in remission.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalHuman Genetics
Issue number3
StatePublished - Jan 1978
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics


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