Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population

Ming Dong, Jinxin Li, Ruqi Tang, Ping Zhu, Fang Qiu, Chan Wang, Jie Qiu, Lan Wang, Yaping Dai, Ping Xu, Yueqiu Gao, Chongxu Han, Yongzhong Wang, Jian Wu, Xudong Wu, Kui Zhang, Na Dai, Weihao Sun, Jianpo Zhou, Zhigang HuLei Liu, Yuzhang Jiang, Jinshan Nie, Yi Zhao, Yuhua Gong, Ye Tian, Hualiang Ji, Zhijun Jiao, Po Jiang, Xingjuan Shi, Rohil Jawed, Yu Zhang, Qinghai Huang, Enling Li, Yiran Wei, Wei Xie, Weifeng Zhao, Xiang Liu, Xiang Zhu, Hong Qiu, Gengsheng He, Weichang Chen, Michael F Seldin, M. Eric Gershwin, Xiangdong Liu, Xiong Ma

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Multiple genome-wide association studies of primary biliary cirrhosis (PBC) in both European and Japanese ancestries have shown significant associations of many genetic loci contributing to the susceptibility to PBC. Major differences in susceptibility loci between these two population groups were observed. In this study, we examined whether the most significant loci observed in either European and/or Japanese cohorts are associated with PBC in a Han Chinese population. In 1070 PBC patients and 1198 controls, we observed highly significant associations at CD80 (rs2293370, P = 2.67 × 10−8) and TNFSF15 (rs4979462, P = 3.86 × 10−8) and significant associations at 17q12-21 (rs9303277), PDGFB (rs715505), NF-κB1 (rs7665090), IL12RB2 (rs11209050), and STAT4 (rs7574865; all corrected P values

Original languageEnglish (US)
Pages (from-to)316-321
Number of pages6
JournalClinical Reviews in Allergy and Immunology
Volume48
Issue number2-3
DOIs
StatePublished - Jun 1 2015

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Keywords

  • Genetic susceptibility
  • Genotyping
  • Han Chinese
  • Primary biliary cirrhosis
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Dong, M., Li, J., Tang, R., Zhu, P., Qiu, F., Wang, C., Qiu, J., Wang, L., Dai, Y., Xu, P., Gao, Y., Han, C., Wang, Y., Wu, J., Wu, X., Zhang, K., Dai, N., Sun, W., Zhou, J., ... Ma, X. (2015). Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population. Clinical Reviews in Allergy and Immunology, 48(2-3), 316-321. https://doi.org/10.1007/s12016-015-8472-0