Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population

Ming Dong, Jinxin Li, Ruqi Tang, Ping Zhu, Fang Qiu, Chan Wang, Jie Qiu, Lan Wang, Yaping Dai, Ping Xu, Yueqiu Gao, Chongxu Han, Yongzhong Wang, Jian Wu, Xudong Wu, Kui Zhang, Na Dai, Weihao Sun, Jianpo Zhou, Zhigang Hu & 26 others Lei Liu, Yuzhang Jiang, Jinshan Nie, Yi Zhao, Yuhua Gong, Ye Tian, Hualiang Ji, Zhijun Jiao, Po Jiang, Xingjuan Shi, Rohil Jawed, Yu Zhang, Qinghai Huang, Enling Li, Yiran Wei, Wei Xie, Weifeng Zhao, Xiang Liu, Xiang Zhu, Hong Qiu, Gengsheng He, Weichang Chen, Michael F Seldin, M. Eric Gershwin, Xiangdong Liu, Xiong Ma

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Multiple genome-wide association studies of primary biliary cirrhosis (PBC) in both European and Japanese ancestries have shown significant associations of many genetic loci contributing to the susceptibility to PBC. Major differences in susceptibility loci between these two population groups were observed. In this study, we examined whether the most significant loci observed in either European and/or Japanese cohorts are associated with PBC in a Han Chinese population. In 1070 PBC patients and 1198 controls, we observed highly significant associations at CD80 (rs2293370, P = 2.67 × 10−8) and TNFSF15 (rs4979462, P = 3.86 × 10−8) and significant associations at 17q12-21 (rs9303277), PDGFB (rs715505), NF-κB1 (rs7665090), IL12RB2 (rs11209050), and STAT4 (rs7574865; all corrected P values

Original languageEnglish (US)
Pages (from-to)316-321
Number of pages6
JournalClinical Reviews in Allergy and Immunology
Volume48
Issue number2-3
DOIs
StatePublished - Jun 1 2015

Fingerprint

Biliary Liver Cirrhosis
Population
Proto-Oncogene Proteins c-sis
Genetic Loci
Genome-Wide Association Study
Population Groups

Keywords

  • Genetic susceptibility
  • Genotyping
  • Han Chinese
  • Primary biliary cirrhosis
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population. / Dong, Ming; Li, Jinxin; Tang, Ruqi; Zhu, Ping; Qiu, Fang; Wang, Chan; Qiu, Jie; Wang, Lan; Dai, Yaping; Xu, Ping; Gao, Yueqiu; Han, Chongxu; Wang, Yongzhong; Wu, Jian; Wu, Xudong; Zhang, Kui; Dai, Na; Sun, Weihao; Zhou, Jianpo; Hu, Zhigang; Liu, Lei; Jiang, Yuzhang; Nie, Jinshan; Zhao, Yi; Gong, Yuhua; Tian, Ye; Ji, Hualiang; Jiao, Zhijun; Jiang, Po; Shi, Xingjuan; Jawed, Rohil; Zhang, Yu; Huang, Qinghai; Li, Enling; Wei, Yiran; Xie, Wei; Zhao, Weifeng; Liu, Xiang; Zhu, Xiang; Qiu, Hong; He, Gengsheng; Chen, Weichang; Seldin, Michael F; Gershwin, M. Eric; Liu, Xiangdong; Ma, Xiong.

In: Clinical Reviews in Allergy and Immunology, Vol. 48, No. 2-3, 01.06.2015, p. 316-321.

Research output: Contribution to journalArticle

Dong, M, Li, J, Tang, R, Zhu, P, Qiu, F, Wang, C, Qiu, J, Wang, L, Dai, Y, Xu, P, Gao, Y, Han, C, Wang, Y, Wu, J, Wu, X, Zhang, K, Dai, N, Sun, W, Zhou, J, Hu, Z, Liu, L, Jiang, Y, Nie, J, Zhao, Y, Gong, Y, Tian, Y, Ji, H, Jiao, Z, Jiang, P, Shi, X, Jawed, R, Zhang, Y, Huang, Q, Li, E, Wei, Y, Xie, W, Zhao, W, Liu, X, Zhu, X, Qiu, H, He, G, Chen, W, Seldin, MF, Gershwin, ME, Liu, X & Ma, X 2015, 'Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population', Clinical Reviews in Allergy and Immunology, vol. 48, no. 2-3, pp. 316-321. https://doi.org/10.1007/s12016-015-8472-0
Dong, Ming ; Li, Jinxin ; Tang, Ruqi ; Zhu, Ping ; Qiu, Fang ; Wang, Chan ; Qiu, Jie ; Wang, Lan ; Dai, Yaping ; Xu, Ping ; Gao, Yueqiu ; Han, Chongxu ; Wang, Yongzhong ; Wu, Jian ; Wu, Xudong ; Zhang, Kui ; Dai, Na ; Sun, Weihao ; Zhou, Jianpo ; Hu, Zhigang ; Liu, Lei ; Jiang, Yuzhang ; Nie, Jinshan ; Zhao, Yi ; Gong, Yuhua ; Tian, Ye ; Ji, Hualiang ; Jiao, Zhijun ; Jiang, Po ; Shi, Xingjuan ; Jawed, Rohil ; Zhang, Yu ; Huang, Qinghai ; Li, Enling ; Wei, Yiran ; Xie, Wei ; Zhao, Weifeng ; Liu, Xiang ; Zhu, Xiang ; Qiu, Hong ; He, Gengsheng ; Chen, Weichang ; Seldin, Michael F ; Gershwin, M. Eric ; Liu, Xiangdong ; Ma, Xiong. / Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population. In: Clinical Reviews in Allergy and Immunology. 2015 ; Vol. 48, No. 2-3. pp. 316-321.
@article{aec2f5a8356149ea9d394cda49e82b0e,
title = "Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population",
abstract = "Multiple genome-wide association studies of primary biliary cirrhosis (PBC) in both European and Japanese ancestries have shown significant associations of many genetic loci contributing to the susceptibility to PBC. Major differences in susceptibility loci between these two population groups were observed. In this study, we examined whether the most significant loci observed in either European and/or Japanese cohorts are associated with PBC in a Han Chinese population. In 1070 PBC patients and 1198 controls, we observed highly significant associations at CD80 (rs2293370, P = 2.67 × 10−8) and TNFSF15 (rs4979462, P = 3.86 × 10−8) and significant associations at 17q12-21 (rs9303277), PDGFB (rs715505), NF-κB1 (rs7665090), IL12RB2 (rs11209050), and STAT4 (rs7574865; all corrected P values",
keywords = "Genetic susceptibility, Genotyping, Han Chinese, Primary biliary cirrhosis, Single nucleotide polymorphism",
author = "Ming Dong and Jinxin Li and Ruqi Tang and Ping Zhu and Fang Qiu and Chan Wang and Jie Qiu and Lan Wang and Yaping Dai and Ping Xu and Yueqiu Gao and Chongxu Han and Yongzhong Wang and Jian Wu and Xudong Wu and Kui Zhang and Na Dai and Weihao Sun and Jianpo Zhou and Zhigang Hu and Lei Liu and Yuzhang Jiang and Jinshan Nie and Yi Zhao and Yuhua Gong and Ye Tian and Hualiang Ji and Zhijun Jiao and Po Jiang and Xingjuan Shi and Rohil Jawed and Yu Zhang and Qinghai Huang and Enling Li and Yiran Wei and Wei Xie and Weifeng Zhao and Xiang Liu and Xiang Zhu and Hong Qiu and Gengsheng He and Weichang Chen and Seldin, {Michael F} and Gershwin, {M. Eric} and Xiangdong Liu and Xiong Ma",
year = "2015",
month = "6",
day = "1",
doi = "10.1007/s12016-015-8472-0",
language = "English (US)",
volume = "48",
pages = "316--321",
journal = "Clinical Reviews in Allergy and Immunology",
issn = "1080-0549",
publisher = "Humana Press",
number = "2-3",

}

TY - JOUR

T1 - Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population

AU - Dong, Ming

AU - Li, Jinxin

AU - Tang, Ruqi

AU - Zhu, Ping

AU - Qiu, Fang

AU - Wang, Chan

AU - Qiu, Jie

AU - Wang, Lan

AU - Dai, Yaping

AU - Xu, Ping

AU - Gao, Yueqiu

AU - Han, Chongxu

AU - Wang, Yongzhong

AU - Wu, Jian

AU - Wu, Xudong

AU - Zhang, Kui

AU - Dai, Na

AU - Sun, Weihao

AU - Zhou, Jianpo

AU - Hu, Zhigang

AU - Liu, Lei

AU - Jiang, Yuzhang

AU - Nie, Jinshan

AU - Zhao, Yi

AU - Gong, Yuhua

AU - Tian, Ye

AU - Ji, Hualiang

AU - Jiao, Zhijun

AU - Jiang, Po

AU - Shi, Xingjuan

AU - Jawed, Rohil

AU - Zhang, Yu

AU - Huang, Qinghai

AU - Li, Enling

AU - Wei, Yiran

AU - Xie, Wei

AU - Zhao, Weifeng

AU - Liu, Xiang

AU - Zhu, Xiang

AU - Qiu, Hong

AU - He, Gengsheng

AU - Chen, Weichang

AU - Seldin, Michael F

AU - Gershwin, M. Eric

AU - Liu, Xiangdong

AU - Ma, Xiong

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Multiple genome-wide association studies of primary biliary cirrhosis (PBC) in both European and Japanese ancestries have shown significant associations of many genetic loci contributing to the susceptibility to PBC. Major differences in susceptibility loci between these two population groups were observed. In this study, we examined whether the most significant loci observed in either European and/or Japanese cohorts are associated with PBC in a Han Chinese population. In 1070 PBC patients and 1198 controls, we observed highly significant associations at CD80 (rs2293370, P = 2.67 × 10−8) and TNFSF15 (rs4979462, P = 3.86 × 10−8) and significant associations at 17q12-21 (rs9303277), PDGFB (rs715505), NF-κB1 (rs7665090), IL12RB2 (rs11209050), and STAT4 (rs7574865; all corrected P values

AB - Multiple genome-wide association studies of primary biliary cirrhosis (PBC) in both European and Japanese ancestries have shown significant associations of many genetic loci contributing to the susceptibility to PBC. Major differences in susceptibility loci between these two population groups were observed. In this study, we examined whether the most significant loci observed in either European and/or Japanese cohorts are associated with PBC in a Han Chinese population. In 1070 PBC patients and 1198 controls, we observed highly significant associations at CD80 (rs2293370, P = 2.67 × 10−8) and TNFSF15 (rs4979462, P = 3.86 × 10−8) and significant associations at 17q12-21 (rs9303277), PDGFB (rs715505), NF-κB1 (rs7665090), IL12RB2 (rs11209050), and STAT4 (rs7574865; all corrected P values

KW - Genetic susceptibility

KW - Genotyping

KW - Han Chinese

KW - Primary biliary cirrhosis

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=84940007076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940007076&partnerID=8YFLogxK

U2 - 10.1007/s12016-015-8472-0

DO - 10.1007/s12016-015-8472-0

M3 - Article

VL - 48

SP - 316

EP - 321

JO - Clinical Reviews in Allergy and Immunology

JF - Clinical Reviews in Allergy and Immunology

SN - 1080-0549

IS - 2-3

ER -