Multiple gating modes and the effect of modulating factors on the μI sodium channel

Jiuying Zhou, Jerald F. Potts, James Trimmer, William S. Agnew, Fred J. Sigworth

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Macroscopic current from the μI skeletal muscle sodium channel expressed in Xenopus oocytes shows inactivation with two exponential components. The major, slower component's amplitude decreases with rapid pulsing. When μI cRNA is coinjected with rat skeletal muscle or brain mRNA the faster component becomes predominant. Individual μI channels switch between two principal gating modes, opening either only once per depolarization, or repeatedly in long bursts. These two modes differ in both activation and inactivation kinetics. There is also evidence for additional gating modes. It appears that the equilibrium among gating modes is influenced by a modulating factor encoded in rat rat skeletal muscle and brain mRNA. The modal gating is similar to that observed in hyperkalemic periodic paralysis.

Original languageEnglish (US)
Pages (from-to)775-785
Number of pages11
JournalNeuron
Volume7
Issue number5
DOIs
StatePublished - 1991
Externally publishedYes

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Sodium Channels
Skeletal Muscle
Hyperkalemic Periodic Paralysis
Complementary RNA
Messenger RNA
Brain
Xenopus
Oocytes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zhou, J., Potts, J. F., Trimmer, J., Agnew, W. S., & Sigworth, F. J. (1991). Multiple gating modes and the effect of modulating factors on the μI sodium channel. Neuron, 7(5), 775-785. https://doi.org/10.1016/0896-6273(91)90280-D

Multiple gating modes and the effect of modulating factors on the μI sodium channel. / Zhou, Jiuying; Potts, Jerald F.; Trimmer, James; Agnew, William S.; Sigworth, Fred J.

In: Neuron, Vol. 7, No. 5, 1991, p. 775-785.

Research output: Contribution to journalArticle

Zhou, J, Potts, JF, Trimmer, J, Agnew, WS & Sigworth, FJ 1991, 'Multiple gating modes and the effect of modulating factors on the μI sodium channel', Neuron, vol. 7, no. 5, pp. 775-785. https://doi.org/10.1016/0896-6273(91)90280-D
Zhou, Jiuying ; Potts, Jerald F. ; Trimmer, James ; Agnew, William S. ; Sigworth, Fred J. / Multiple gating modes and the effect of modulating factors on the μI sodium channel. In: Neuron. 1991 ; Vol. 7, No. 5. pp. 775-785.
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