Multiple Forms of Aromatase in Suiformes

Tissue Distribution, Regulation, and Functional Significance

Alan J Conley, Veronica N. Orr, Brian C. Trainor, Trish Berger, Austin Hughes

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Pigs have three CYP19 genes encoding functional paralogues of aromatase cytochrome P450 expressed tissue specifically in the gonads/hypothalamus, placenta, and preimplantation blastocyst. Gene duplication is predicted to have relaxed selection pressure and allowed evolution of enzyme function. All isozymes catalyze estrogen synthesis. However, the "gonadal/ hypothalamic" form (ghP450arom) is unique among mammalian aromatases in also synthesizing a nonaromatizable, biopotent testosterone metabolite, 1OH-testosterone (1OH-T) that is hypothesized to have promoted increased ovulation rate and litter size. High ghP450arom expression in porcine testis facilitates study of differential regulation in hypothalamus and gonads that is not possible in other species. These, the first such studies in pig brain, demonstrate unusual aspects of P450arom expression and regulation in the hypothalamus, offering promise of gaining better insight into roles of P450arom in reproductive function.

Original languageEnglish (US)
Title of host publicationBrain Aromatase, Estrogens, and Behavior
PublisherOxford University Press
ISBN (Print)9780199979837, 9780199841196
DOIs
StatePublished - Jan 24 2013

Fingerprint

Aromatase
Tissue Distribution
Hypothalamus
Swine
Gonads
Testosterone
Litter Size
Gene Duplication
Blastocyst
Ovulation
Cytochrome P-450 Enzyme System
Placenta
Isoenzymes
Testis
Estrogens
Pressure
Brain
Enzymes
Genes

Keywords

  • Aromatase
  • Domestic pig
  • Evolution
  • Gene duplication
  • Gonads
  • Hypothalamus
  • Placenta
  • Reproductive function
  • Suiforme

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Conley, A. J., Orr, V. N., Trainor, B. C., Berger, T., & Hughes, A. (2013). Multiple Forms of Aromatase in Suiformes: Tissue Distribution, Regulation, and Functional Significance. In Brain Aromatase, Estrogens, and Behavior Oxford University Press. https://doi.org/10.1093/acprof:oso/9780199841196.003.0004

Multiple Forms of Aromatase in Suiformes : Tissue Distribution, Regulation, and Functional Significance. / Conley, Alan J; Orr, Veronica N.; Trainor, Brian C.; Berger, Trish; Hughes, Austin.

Brain Aromatase, Estrogens, and Behavior. Oxford University Press, 2013.

Research output: Chapter in Book/Report/Conference proceedingChapter

Conley, AJ, Orr, VN, Trainor, BC, Berger, T & Hughes, A 2013, Multiple Forms of Aromatase in Suiformes: Tissue Distribution, Regulation, and Functional Significance. in Brain Aromatase, Estrogens, and Behavior. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780199841196.003.0004
Conley AJ, Orr VN, Trainor BC, Berger T, Hughes A. Multiple Forms of Aromatase in Suiformes: Tissue Distribution, Regulation, and Functional Significance. In Brain Aromatase, Estrogens, and Behavior. Oxford University Press. 2013 https://doi.org/10.1093/acprof:oso/9780199841196.003.0004
Conley, Alan J ; Orr, Veronica N. ; Trainor, Brian C. ; Berger, Trish ; Hughes, Austin. / Multiple Forms of Aromatase in Suiformes : Tissue Distribution, Regulation, and Functional Significance. Brain Aromatase, Estrogens, and Behavior. Oxford University Press, 2013.
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